Clinical features and history Cutaneous B-cell lymphomas usually present as one or more erythematous papules or nodules that may coalesce to form plaques. They are usually localized tumors effecting one cutaneous region and rarely ulcerate. There is some regional predilection for various sub-types of tumors; follicle center lymphoma more commonly arises on the scalp, marginal zone B-cell lympho...

Tumors of the splenic marginal zone can present in spleen or blood. The maturational status of the neoplastic B cells from each site appears heterogeneous, with either unmutated or mutated variableregion heavy chain (VH) genes. To determine an influence of tissue location, we assessed matched blood and splenic tumor cells from 4 patients and found them identical. However, one patient with unmut...

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been applied to patients with diffuse large Bcell lymphoma (DLBCL); it is well established that ASCT shows significant survival benefits for chemosensitive relapse. However, half of relapsed patients are resistant to salvage chemotherapy, indicating that they are not suitable for ASCT. We retrospectively analyzed...

EMEA has approved Y-radiolabelled ibritumomab tiuxetan, Zevalin, in Europe for the treatment of adult patients with rituximab-relapsed or -refractory CD20+ follicular Bcell non-Hodgkin ́s lymphoma (NHL) in January 2004. The number of European nuclear medicine departments using Zevalin is continuously increasing, since the therapy is often considered successful. The Therapy-, the Oncologyand the ...

B-chronic lymphocytic leukemia (B-CLL)/Small lymphocytic lymphoma (SLL) is a neoplastic, lymphoproliferative disease, characterized by accumulation of small, mature lymphocytes of the Bcell line in the blood, bone marrow and lymphoid tissues. CLL and SLL are different manifestations of the same disease. The major difference is that in CLL a significant number of the abnormal lymphocytes are als...

The CD-19-directed immunotoxin anti-B4-blocked ricin (antiB4-bR) is currently in clinical trials for the treatment of Bcell malignancies. To explore the potential of using antiB4-bR with chemotherapy protocols we tested the in vivo efficacy of the immunotoxin in combination with two multidrug chemotherapeutic regimens in severe combined immunodeficient (SCID) mice bearing disseminated tumors of...

Situated among the rare bone tumors, the primary di use large B-cell lymphoma occupies a well-worth place in doctor’s attention given the di culty of diagnosis and the speci c treatment, as well as the high lay time in showing of the clinical features. Biopsy followed by imunohistochemistry is the gold standard in investigations. e presentation that follows shows a rare case of the primary di u...

Introduction: MALT (mucosa associated lymphoid tissue) lymphomas comprise a heterogeneous group, originally thought to be derived from the marginal zone B­cells that are found surrounding B­cell follicles and within the adjacent lymphoepithelium. They arise most commonly in extranodal organs such as the stomach, major salivary glands and thyroid. Thus, they can be precisely described as extrano...

Abnormal hair development and regeneration occurs in some skin diseases, including lymphomas when hair follicles are eliminated. Otherwise, neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp. In lymphomas alopecia can develop due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. Total -body ...