Benzimidazole derivatives are known to represent a class of medicinally important compounds which are extensively used in drug design and catalysis. A series of 2-substituted benzimidazole derivatives 10a-i was herein synthesized from the reaction of o-phenylenediamine with some amino acids using ameliorable pathway. The chemical structures of the synthesized compounds were confirmed by IR, UV,...

Benzimidazole is the heterocyclic compound formed from benzene and imidazole ring containing nitrogen, oxygen sulphor and its derivatives are of wide interest because of their diverse biological activity and clinical applications, they are remarkably effective compounds both with respect to their inhibitory activity and their favourable selectivity ratio. Reported nucleus is a constituent of vi...

Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C. This reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high...

A series of 1-(1H-benzimidazol-2-yl)-3-(substituted)-2-propen-1-one and its 1-methyl analogues 2c-h were synthesized and cyclized with different reagents such as ethyl cyanoacetate, thiourea, hydroxylamine hydrochloride, guanidinium sulfate, methylhydrazine, phenylhydrazine and/or hydrogen peroxide in different reactions to produce pyridones 3a,b, pyrimidinethione 4a,b, isoxazole 5a,b, aminopyr...

Benzimidazole derivates play vital role in biological field such as antimicrobial, antiviral, antidiabetic, and anticancer activity. Therapeutic significance of these clinically useful drugs in treatment of microbial infections encouraged the development of some more potent and significant compounds. With the purpose of finding new chemical entities with enhanced antimicrobial activity, a serie...

ABSTRACT A series of new benzimidazole and benzotriazole derivatives containing a tetrazole moiety was synthesized by N-alkylation of 5-aryltetrazole with 4,5,6,7-tetrabromo-1-(3-chloropropyl)-1H-benzimidazole and 4,5,6,7-tetrabromo-2-(3-chloropropyl)-2H-benzotriazole. The reaction was regioselective and mostly 2,5-disubstituted tetrazole derivatives were obtained. The effect of all synthesized...

Phospho sulfonic acid (PSA) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) A very simple, green and efficient procedure for the synthesis of benzimidazole and also benz...

phospho sulfonic acid (psa) synthesized as an environmentally safe and efficient solid acid catalyst, and it used for the synthesis of several 2-disubstituted benzimidazoles, 2-substituted benzoxazoles, and 2-substituted quinoxalines in ethanol as a green solvent at ambient temperature is described. (i) a very simple, green and efficient procedure for the synthesis of benzimidazole and also benz...

New benzimidazole derivatives (benzimidazole-nitrone) were synthesized from the condensation of o-phenylene diamine with p-amino benzaldehyde in presence (P-TSOH\EtOH) then compounds that containing an imine group oxidized to obtain a nitrone by used peracetic acid and identified FT-IR, H1-NMR spectra, elemental analysis. all applied candida aspergillus fungi gave different result. The have Ph,...

The purpose of the present study was to identify the cellular processes and targets affected by treatment with bis-benzimidazole derivatives with chloroalkyl and bromoalkyl moieties (1–4) in the estrogen receptor-negative MDA-MB-231 human breast cancer cells. Treatment of the cells revealed that these compounds inhibited DNA synthesis and irreversibly inhibited the proliferative activity of the...