نتایج جستجو برای: benzimidazolone
تعداد نتایج: 55 فیلتر نتایج به سال:
Background: The transcriptional repressor BCL6 is an oncogenic driver often found to be deregulated in lymphoid malignancies. We report the optimisation of our previously reported benzimidazolone molecular glue type degrader CCT369260 CCT373566, a highly potent probe suitable for sustained depletion vivo. Materials and methods: Key discovering CCT373566 were two design approaches: 1) careful, p...
The photochemistry of tetrazolones derived from the carbocyclic allylic alcohols cyclohex-2-enol and 3-methylcyclohex-2-enol and from the natural terpene alcohol nerol was investigated in solution with the aim of assessing the effect of solvent and of structural constraints imposed by bulky allylic moieties on photoproduct selectivity and stability. Photolysis of tetrazolones derived from nerol...
A knowledge-based library of 2,3-dichlorophenylsulfonyl derivatives of commercially available aryl amines was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme. Hits were required to be more potent than an existing indazole series, have better physicochemical properties (clogP <3.5, chrom logD₇.₄ <5.3 and CLND ...
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