Despite the widespread use of benzotriazoles and benzothiazoles and the occurrence of these compounds in wastewater treatment plants (WWTPs), no earlier study has comprehensively examined their fate in WWTPs. In this study, an integrated liquid chromatography-tandem mass spectrometry (LC–ESI(+)MS/MS) method was developed and validated for simultaneous determination of four benzotriazoles and fo...

An enantioselective hydrogenation of fluorinated hydrazones has been achieved by employing [Pd(R)-DTBM-SegPhos(OCOCF3)2] as the catalyst, providing a general and convenient method toward chiral fluorinated hydrazines. A broad substrate scope including β-aryl-, γ-aryl-, and alkyl-chain-substituted hydrazones worked efficiently in high yields and up to 94% of enantioselectivity. The reductive ami...

On the basis of exhaustive literature review, it has been found that benzothiazole derivatives have good potential to exhibit anticancer activity15-17. So the present study involves the synthesis of 2,6-disubstituted benzothiazole followed by preliminary cytotoxicity screening against three human cancer cell lines( MCF-7, HeLa and MG63) using MTT assay at 48 h of exposure.

The synthesis of a new type of pentacyclic benzothiazolium compound 6,13-dihydropyrazino[2,1-b:5,4-b ́]bis(1,3-benzothiazole)-7,14-diiumdibromide (2), is reported. Compound 2 was prepared by dimerization of 2-(bromomethyl)benzothiazole. Quantum chemical calculation studies have been carried out on the structures of possible isomers of 2, as well as the products of its deprotonation reactions.

Ascorbate Determination, 2,4-Dinitrophenylhydrazine Microamounts of vitamin C could be readily determined in 20 ul-samples using the 2,4-dinitrophenylhydrazine method together with separation by thin layer chromato­ graphy. The condensation reaction was carried out for 5 min at 100 °C on a glass fibre disc. Purification of vitamin C hydrazones was accomplished by repeated separation on TLC plat...

α,β-Unsaturated N,N-dialkyl hydrazones undergo a mild [2 + 2] cycloaddition to allenamides when treated with a suitable gold catalyst. The method, which represents the first application of N,N-dialkyl hydrazones in gold catalysis, is compatible with a wide variety of substituents at the alkenyl moiety of the hydrazone component, proceeds with excellent levels of regio- and diastereoselectivity,...

Hydrazones and their derivatives constitute a versatile class of compounds in organic chemistry. The development of novel hydrazones containing compounds possess a wide verities of biological activities like as antioxidant, anti-inflammatory, anticonvulsants, antidepressant and anxiolytic, antihypertensive, anticancer, antimicrobial, anti-tuberculosis, and antifungal activity. Hydrazones posses...

Benzothiazole-2-sulfonate (BTSO3) is one of the side products occurring in 2-mercaptobenzothiazole (MBT) production wastewater. We are the first to isolate an axenic culture capable of BTSO3 degradation. The isolate was identified as a Rhodococcus erythropolis strain and also degraded 2-hydroxybenzothiazole (OBT) and benzothiazole (BT), but not MBT, which was found to inhibit the biodegradation...

The present study describes an efficient and ecofriendly, ultrasound, one-pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3-triazoles tethered with fluorinated 1,2,4-triazole-benzothiazole molecular conjugates. It involved three-component condensation of the appropriate bromoacetamide benzothiazole, sodium azide and 4-alkyl/aryl-5-(2-fluorophenyl...

4-methylaniline in chlorobenzene reacted with sulphuric acid, sodium thiocyanate and sulfuryl chloride to give 2-amino-6-methyl benzothiazole. This 2-amino-6methyl benzothiazole was later further reacted with 2-(2,2difluoroethoxy)-6-(trifluoromethyl)benzene-1-sulfonyl chloride in the presence of Dichloromethane and anhydrous Pyridine to afford 2-(2,2-difluoroethoxy)-N-(6methylbenzo[d]thiazole-2...