BACKGROUND The emergence of drug resistant pathogens becomes a crucial problem for infectious diseases worldwide. Among these bacteria, Pseudomonas aeruginosa is one of which highly resists to many currently used drugs and becomes a major concern in public health. Up till now, the search for potential antimicrobial agents has been still a challenge for researchers. METHODS Broth microdilution...

the aim of this paper was to investigate the antibacterial potential of kelussia odoratissima mozff extract against gram-negative and gram-positive bacteria. karafs-ekoohi with the scientific name of kelussia odoratissima is an iranian endemic edible plant in the middle region of iran with enormous use as food, spice and medicinal herb . the antibacterial effect of the extracts was investigated...

BACKGROUND Multi-drug resistance of Gram-negative bacteria constitutes a major obstacle in the antibacterial fight worldwide. The discovery of new and effective antimicrobials and/or resistance modulators is necessary to combat the spread of resistance or to reverse the multi-drug resistance. In this study, we investigated the antibacterial and antibiotic-resistance modifying activities against...

BACKGROUND In the present study, the methanol extracts from the leaves, as well as compounds namely sigmoidin I (1), atalantoflavone (2), bidwillon A (3), neocyclomorusin (4), 6α-hydroxyphaseollidin (5) and neobavaisoflavone (6) (from the bark extract) were tested for their activities against a panel of Gram-negative bacteria including multi-drug resistant (MDR) phenotypes. METHODS Broth micr...

Abstract High resistance to antimicrobials is associated with biofilm formation responsible for infectious microbes withstand severe conditions. Therefore, new alternatives are necessary as inhibitors control infections. In this study, the antimicrobial and antibiofilm activities of Fagonia indica extracts were evaluated against MDR clinical isolates. The extract exhibited its effect by alterin...

BACKGROUND Recinodindron heudelotii (Euphorbiaceae) is a plant used in Africa, particularly in Cameroon to treat various ailments including bacterial infections. In this study, we evaluated the extracts of the leaves (RHL) and bark (RHB) of R. heudelotii for their antibacterial and antibiotic resistance modulating activities against 29 Gram-negative bacteria, including multidrug-resistant (MDR)...

conclusions vancomycin, but not teicoplanin, can be considered an effective antibiotic of choice for controlling infections caused by mdr cons in gorgan, depending on the bacterial species. background coagulase-negative staphylococci (cons) are clinically important, especially in nosocomial and neonatal infections. the increasing emergence of glycopeptide-resistant cons has made these agents th...

The present study evaluates the synergistic effect of sulbactam/tazobactam in combination with meropenem or colistin against multidrug resistant (MDR) Acinetobacter baumannii isolated from hospitalized patients from a tertiary care hospital in Saudi Arabia. During the study period, 54 multidrug and carbapenem-resistant isolates of A. baumannii isolates were collected from blood and respiratory ...

Minimum inhibitory concentrations of carbenicillin, ticarcillin, and BL-P1654 were determined for 89 clinical isolates of Pseudomonas aeruginosa. Ticarcillin was generally twice as active and BL-P1654 eight to 16 times as active as carbenicillin. Usually carbenicillin and ticarcillin killed at the same concentration or twice the concentration needed to inhibit, whereas 400 mug of BL-P1654 per m...

The effects of combinations of ampicillin and chloramphenicol against seven strains of Haemophilus influenzae type b (five beta-lactamase-negative and two beta-lactamase-positive strains) were evaluated by killing-kinetic methods. Growth of strains was assessed in modified Levinthal broth against an inoculum of 10(5) organisms per ml; colony counts were performed immediately and at 6 and 20 h p...