conclusions according to our results, blatem-116 was the most frequent isolated esbl gene among the p. aeruginosa strains isolated from patients. results ciprofloxacin and piperacillin were the most efficient antipseudomonal agents. the results disclosed that 19 (16.37%) of the isolates were multidrug resistant and 8 (6.89%) were esbl-positive. of the 116 isolates, 30 (25.86%) were resistant to...

conclusions epidemiological and regional evaluation of mbl-producing p. aeruginosa through simple and inexpensive methods should be considered for effective treatment of carbapenem-resistant p. aeruginosa infections. results amongst all the p. aeruginosa isolates, 58.7% were resistant to imipenem while 31.8%, 13.5% and 74.4% were resistant to meropenem, doripenem and ertapenem, respectively. am...

The comparative activities of ampicillin, cefamandole, cefoxitin, cefaclor, and cefatrizine against both beta-lactamase-producing and non-beta-lactamase-producing isolates of Haemophilus influenzae were determined by using an agar dilution susceptibility test procedure. Ampicillin was the most active drug tested against non-beta-lactamase-producing isolates, whereas cefamandole was most active ...

The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga, even beta-lactamase producers, indi...

introduction: pseudomonas aeruginosa is a serious challenge for antimicrobial therapy, due to chromosomal mutations or intrinsic resistance to various antimicrobial agents, such as metallo-β-lactams (mbl). this study aimed to investigate the prevalence of β-lactamases encoding genes among p. aeruginosa strains isolated from intensive care unit (icu) patients by phenotypic and multiplex pcr meth...

OBJECTIVES Isolates previously identified as Citrobacter diversus are now known as Citrobacter koseri. We measured sequence variation at the beta-lactamase structural gene among a group of clinical isolates originally identified as C. diversus by API 20E profiling. METHODS beta-Lactamase and 16S rRNA genes were amplified by PCR and sequenced by standard methods. beta-Lactamase induction was a...

Using clinical strains of Serratia marcescens with low and high resistance to extended-spectrum beta-lactam antibiotics, the relative contribution of chromosomal beta-lactamase and defective outer membrane porins to resistance was determined. Low-level resistance was caused by overproduced beta-lactamase alone. High-level resistance was due to beta-lactamase overproduction and defects of porin ...

the nosocomial infections, caused by multi-drug resistant bacteria, are the most important cause of mortality throughout the world. one important mechanism against beta-lactam antibiotics is the production of beta-lactamases. enterobacteriaceae and non-fermentative bacteria, like pseudomonas aeruginosa and acinetobacter baumannnii may produce these enzymes. currently, there is no vaccine to pre...

Lincomycin increased the TEM-2 beta-lactamase activity of Escherichia coli K-12 cells carrying plasmid RP4 at a concentration which slightly inhibited cell growth. In a control culture beta-lactamase activity reached its maximal level in late log phase, whereas when lincomycin was present beta-lactamase activity continued to increase into the stationary phase. Lincomycin (100 micrograms/ml) inh...