As the Editor-in-Chief of JPIS, I cannot stress enough the importance of the Journal Article Tag Suite (JATS) markup language, even if it may be new to our readers, authors, and reviewers. JATS is an XML format used to encode scientific literature for online publication. It functions as a technical standard developed by the National Information Standards Organization (NISO) in the United States...

background: factor viii administration to hemophilia a patients results in an immune response (inhibitor formation) which significantly complicates the therapy. the present study was performed to determine the prevalence of inhibitor development in hemophilia a patients receiving recombinant factor viii therapy. materials and methods: this was an observational descriptive study. clotting factor...

The degree to which clinical perceptions of Papanicolaou smear sensitivity contribute to patient mismanagement is uncertain. A voluntary, anonymous questionnaire was mailed to 350 obstetricians/gynecologists (OGYNs) and 350 other primary care providers (PCPs) located in Pennsylvania or Ohio. The clinicians estimated the probability of no disease, dysplasia, and invasive carcinoma for 1 of 7 Bet...

Specimen Adequacy TBS 1991 reported the adequacy of cervical cytology preparations in three categories: “satisfactory,”“unsatisfactory,”and “satisfactory but limited by,” or SBLB. SBLB included factors such as the lack of transformation zone components and the presence of partially obscuring factors (i.e., blood or inflammation). This category was confusing to some clinicians and prompted unnec...

The aims of The Bethesda System (TBS) were to provide effective communication from the laboratory to the clinical provider; facilitate cytologic-histologic correlation; facilitate research into the epidemiology, biology, and pathology of cervical disease; and provide reproducible and reliable data for national and international statistical analysis comparisons. Dr. Diane Solomon and colleagues'...

OBJECTIVE We aimed to investigate the validity of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) through meta-analysis. STUDY DESIGN All publications between January 1, 2008 and September 1, 2011 that studied TBSRTC and had available histological follow-up data were retrieved. To calculate the sensitivity, specificity and diagnostic accuracy, the cases diagnosed as follicula...

EMARKABLE ADVANCES in technology and in understanding of the development of cervical cancer have opened a new era in cervical cancer screening. In the past few years: • The traditional technique of smearing cervical cells on a glass slide for the Papanicolaou (Pap) test has been largely replaced by a liquid-collection technique • A major trial sponsored by the National Cancer Institute provided...

categories in TBSRTC soon led to the successful introduction of a whole new era of ‘thyroid molecular cytopathology’, with novel tests further enhancing the accuracy of an FNA diagnosis [3, 4] . The success of TBSRTC is reflected in its widespread use by cytopathologists globally, the translation of the monograph into 4 other languages, a large amount of published scientific literature, and its...