Hyaluronic acid, a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously addressed the role of hyaluronic acid in small intestinal and colonic growth in mice. We addressed the role of exogenous hyaluronic acid by giving hyaluronic acid intraperitoneally and the role of endogenous hyaluronic acid by giving PEP-1, a peptide that blocks hyaluro...

Introduction: Oral lichen planus (OLP) is an autoimmune disease with uncertain etiopathogenecity and no definitive treatment. Considering the recurrent nature of OLP, finding an adjunctive treatment to minimize the risk of chronicity and recurrence of OLP and to decrease the adverse effects of corticosteroids can be promising. This study aimed to assess the efficacy of a mixture of hyaluronic a...

the effect of ascorbic acid (aa) and butylated hydroxyanisole (bha) supplementation on aflatoxicosis in broiler chickens (1 to 42 days of age) was investigated (250, 500, 1000 and 2000 ppm for aa and bha) in diet containing 1 ppm total aflatoxin (af: 76.45% afb1, 10.52% afb2, 9.89% afg1 and 3.14% afg2). a total of 300 day-old broiler chicks were divided into ten treatment groups (t1=control; t2...

The effect of ascorbic acid (AA) and butylated hydroxyanisole (BHA) supplementation on aflatoxicosis in broiler chickens (1 to 42 days of age) was investigated (250, 500, 1000 and 2000 ppm for AA and BHA) in diet containing 1 ppm total aflatoxin (AF: 76.45% AFB1, 10.52% AFB2, 9.89% AFG1 and 3.14% AFG2). A total of 300 day-old broiler chicks were divided into ten treatment groups (T1=control; T2...

We previously showed that the cell-permeant antioxidant 2(3)- tert-butyl-4-hydroxyanisole (BHA) inhibited germinal vesicle breakdown (GVBD) in oocyte-cumulus complexes (OCC) of the rat. The objective of the present studies was to assess other antioxidants and whether such inhibition was reversible. Spontaneous GVBD in OCC incubated for 2 h was significantly inhibited ( P < 0.005) by nordihydrog...

AHAs act on both the epidermal and the dermal levels. When applied to the skin, AHAs stimulate the exfoliation of epidermal cells in the stratum corneum (s.c.) by interfering with the ionic bonding between these cells. This results in the sloughing off dull, rough skin and promotes cellular renewal. Initially used for treatment of hyperkeratosis and other skin conditions affecting s.c. turnover...

Synthesis of hyaluronic acid was investigated in a cell-free system derived from a strain of Group A streptococci. Preparative procedures were improved so that an enzyme system 70 times more active than that previously reported was obtained. The hyaluronic acid synthesized could be separated into trichloroacetic acid-soluble and -insoluble fractions. On the basis of pulse-chase experiments, it ...

When the concentration of hyaluronic acid was monitored in primary cultures of mouse skin dermal fibroblasts, there was an increase in hyaluronic acid proportional to the increase in cell number during the logarithmic growth phase. The concentration reached the maximum value 2 days before the cells became confluent, and then decreased gradually. Hyaluronic acid added at 1 mg ml-1 during the log...