The potential for endogenous formation of N-nitrosobis(2-hydroxypropyl)amine (BHP) and car cinogenicity were investigated in male Wistar rats administered tris(2-hydroxypropyl)amine (THPA) mixed in powdered diet at a concentration of 2% and sodium nitrite dissolved in distilled water at concentrations of 0.15% and 0.3% for 102 weeks. Endogenous formation of BHP was demonstrated by its presence ...

We investigated the protective effects of Gymnaster koraiensis against oxidative stress-induced hepatic cell damage. We used two different cytotoxicity models, i.e., the administration of tert-butyl hydroperoxide (t-BHP) and acetaminophen, in HepG2 cells to evaluate the protective effects of G. koraiensis. The ethyl acetate (EA) fraction of G. koraiensis and its major compound, 3,5-di-O-caffeoy...

The mutagenic activity of N-nitrosobis(2-oxopropyl)amine (BOP), N-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), N-nitrosomethyl-2-oxopropylamine (MOP), and N-nitrosomethyl-2-hydroxypropylamine (MHP) was examined in the Ames liquid incubation assay, using hamster liver homogenate for metabolic activation, and in the hamster liver cell-mediated V79 ...

We previously demonstrated that the human nicotinamide N-methytransferase (NNMT) gene was highly expressed in many papillary thyroid cancers and cell lines. The expression in other papillary and follicular cancers or cell lines and normal thyroid cells was low or undetectable. To gain an understanding of the molecular mechanism of this cell-specific expression, the NNMT promoter was cloned and ...

The mutagenic activity of A/-nitrosobis(2-oxopropyl)amine (BOP), A/-nitroso(2-hydroxypropyl) (2-oxopropyl)amine (HPOP), N-nitrosobis(2-hydroxypropyl)amine (BHP), /V-nitrosomethyl-2-oxopropylamine (MOP), and W-nitrosomethyl-2-hydroxypropylamine (MHP) was examined in the Ames liquid incubation assay, using hamster liver homogenate for meta bolic activation, and in the hamster liver cell-mediated ...

N-nitrosobis(2-hydroxypropyl)amine (BHP) is a well-known carcinogen and induces tumors in various tissues. In the present paper, a case of olfactory neuroblastoma (ONB) induced in a rat by BHP is described. The tumor was observed in one out of 25 male rats that received 2000 ppm of BHP in drinking water from 6 to 18 weeks of age and were sacrificed at 26 weeks of age. Histologically, the tumor ...

In recent works [1] (BHP), a generalized universality has been proposed, linking phenomena as dissimilar as 2D magnetism and turbulence. To test these ideas, we performed a MC study of the 2DXY-model. We found that the shape of the probability distribution function for the magnetization M is non Gaussian and independent of the system size, below the Kosterlitz-Thoules temperature. However, the ...

To ensure safe and stable drilling operation, bottom hole pressure (BHP) should be kept within some region. However measurement of the BHP is sometimes not available or reliable, especially when the circulation is low, e.g., during pipe connection procedures. This paper presents the application of a moving horizon estimation (MHE) method for online estimation of the BHP during petroleum drillin...

The concept of cold-formed light steel framing construction has been widespread after understanding its structural characteristics with massive research works over the years. Connection serves as one of the important elements for light steel framing in order to achieve its structural stability. Compared to hot-rolled steel sections, cold-formed steel connections perform dissimilarity due to the...

Organic peroxides and hydroperoxides are skin tumor promoters. Free radical derivatives from these compounds are presumed to be the prominent mediators of tumor promotion. However, the molecular targets of these species are unknown. Phosphatase and tensin homologs deleted on chromosome 10 (PTEN) are tumor suppressors that play important roles in cell growth, proliferation, and cell survival by ...