Analytical and bioanalytical methods of high-performance liquid chromatography with fluorescence detection (HPLC-FLD) were developed and validated for the determination of chloroaluminum phthalocyanine in different formulations of polymeric nanocapsules, plasma and livers of mice. Plasma and homogenized liver samples were extracted with ethyl acetate, and zinc phthalocyanine was used as interna...

In recent years, the threats to the integrity of science posed by the dishonesty of a small minority of scientists, and the biases held by most scientists, have become a topic of lively discussion. We believe that faulty measurement of biochem ical compounds is sufficiently common that it also serves to undermine the integrity and efficiency of science. We approach this neglected area by first ...

In this article, we present a framework and a concrete method to support validation of central database components in application software. We explain how validation can cope with both the need for a formalized evaluation of correctness as well as the need for prototyping high level database speciications in early development phases. We deene diierent levels of correctness suitable for database...

The relative ease of Mössbauer spectroscopy and of density functional theory (DFT) calculations encourages the use of Mössbauer parameters as a validation method for calculations, and the use of calculations as a double check on crystallographic structures. A number of studies have proposed correlations between the computationally determined electron density at the iron nucleus and the observed...

When the assumption of homoscedasticity is not met for analytical data, a simple and effective way to counteract the greater influence of the greater concentrations on the fitted regression line is to use weighted least squares linear regression (WLSLR). The purpose of the present paper is to stress the relevance of weighting schemes for linear regression analysis and to show how this approach ...

In this paper, we study boundary value methods (BVM methods) for solving initial value problems. These methods give some advantages with respect to usual initial value methods for ODES: for instance, BVM methods may be implemented efficiently on parallel computers. We propose two classes of BVM methods based on linear two-step schemes and we study their BVstability regions. The convergence will...