We evaluated the effect of new beta-lactam antibiotics (azlocillin, mezlocillin, piperacillin, cefotaxime, moxalactam, and cefoperazone) on assays for aminoglycosides and vancomycin. These antibiotics produced no interference in an immunoassay for gentamicin and tobramycin. The new penicillins produced no interference in a bioassay of amikacin and vancomycin with penicillinase incorporated into...

A bioassay method was developed to measure the average intensity within a UV disinfection reactor. The survival of spores of Bacillus subtilis was determined as a function of UV dose to prepare a standard curve. Spores were added to unknown systems, and the survival rate was used to determine the average intensity. A modification was used for flow-through reactors by which spores were injected ...

The development of a specific agar diffusion bioassay for the quantitative determination of fluconazole formulated in capsules was carried out using a strain of Candida albicans ATCC 18804 as the test organism. A prospective validation of the method showed adequate linearity (r2=0.9995), precision (R.S.D. = 4.0% for intra-day and 4.5% for inter-day precision) and accuracy (mean recovery = 102.9...

Ceftriaxone (CFTX) sodium is a third-generation, broad-spectrum cephalosporin that is resistant to betalactamases. An alternative bioassay for the assessment of the potency of this drug in pharmaceutical formulations has not been previously reported. Thus, this paper reports the development and full validation of a 3 x 3 agar diffusion bioassay using a cylinder-plate method to quantify CFTX sod...

Abstraet--A continuous tlow bioassay system was designed to measure the effects of outboard motor exhaust (OME) emissions and selected volatile and evaporative aromatic toxicants on goldfish (Carassitts auratus). Continuous flow bioassays were run for 24, 48, 72. 96. and 720h to determine lethal concentrations for 50y.~, of individuals (LC-50"s) for leaded OME, non-leaded OME. toluene, xylene, ...

Dose assessment after intakes of radionuclides requires application of biokinetic and dosimetric models and assumptions about factors influencing the final result. In 2006, a document giving guidance for such assessment was published, commonly referred to as the IDEAS Guidelines. Following its publication, a working group within the European networks CONRAD and EURADOS was established to improv...

Bioassays can be used to estimate the initial intake I for the case of an acute intake exposure for an individual worker. To evaluate the effective dose, apart from I, we need to know other parameters such as activity median aerodynamic diameter (AMAD) or the fraction absorption ( f(1)) in the blood from the GI tract, but in an accident situation these parameters are often unknown. The bioassay...