This study was designed to characterize a heparin-derived oligosaccharide (HDO), C3, using chemical and biochemical methods. Although previous studies have suggested C3 as a promising compound in the treatment of Alzheimer's disease (AD), its molecular and biochemical properties are still unknown. In this study, the molecular profiles and anticoagulant effects of C3 were investigated. To charac...

Adenosine is produced primarily by the metabolism of ATP and mediates its physiological actions by interacting primarily with adenosine receptors (ARs) on the plasma membranes of different cell types in the body. Activation of these G protein-coupled receptors promotes activation of diverse cellular signaling pathways that define their tissue-specific functions. One of the major actions of aden...

The term metabolic profiling is often used to denote the systematic characterization of the unique biochemical trails or fingerprints left behind by cellular processes. Advances in computational biosciences are often invaluable in dealing with the huge amount of raw data generated from the countless biochemical intermediates that flood the cell at any given time. As a prelude to metabolic profi...

three tuberculous, twenty-one non-tuberculous mycobacterial (ntm) reference strains and seventy two isolates classified by biochemical tests were shown to produce specific sets of dna fragments in a polymerase chain reaction with single universal primer (up-pcr). a rather wide limit of tolerance for variations in procedure of pcr mixture preparation and thermocycling parameters was found. there...

Metabolite profiling is the multiparallel relative quantification of a mixture of compounds or compound classes using chromatography and universal detection technologies (GC-MS, LC-MS). In this respect it is an extension of classical single-target methods from which it can be distinguished by its broader view on profiling major biochemical events. This broader scope of analysis outweighs the di...

Ongoing efforts in metabolic profiling of both cultivated and wild plants continue to identify new plant compounds, many of them unique to a single species or found only in closely related species. Such compounds are defined as specialized, or secondary, metabolites and they play many physiological and ecological roles, including in plant-insect and plant-pathogen interactions. To date, only a ...

Regulation of protein synthesis represents a key control point in cellular response to stress. In particular, discreet RNA regulatory elements were shown to allow to selective translation of specific mRNAs, which typically encode for proteins required for a particular stress response. Identification of these mRNAs, as well as the characterization of regulatory mechanisms responsible for selecti...

objective(s): the purpose of this study was to conduct a meta-analysis on human micrornas (mirnas) expression data of endometriosis tissue profiles versus those of normal controls and to identify novel putative diagnostic markers. materials andmethods: pubmed, embase, web of science, ovid medline were used to search for endometriosis mirna expression profiling studies of endometriosis. the mirn...

Abstract Cornelian cherry ( Cornus mas L.) belongs to a group of fruit and nut species growing in Europe considered be underused economically, although it has been recognized as potential regional “superfood” source valuable bioactive compounds. Phenotyping fruits 30 accessions an Austrian wildtype population C. allowed evaluate their nutraceutical potential. Ten per accession were characterize...

the earliest evidences on circulation of avian influenza (ai) virus on the iranian poultry farms date back to 1998. great economic losses through dramatic drop in egg production and high mortality rates are characteristically attributed to h9n2 ai virus. in the present work non-structural (ns) genes of 10 iranian h9n2 chicken ai viruses collected during 1998-2007 were fully sequenced and subjec...