background: extensive full-thickness burns require replacement of both epidermis and dermis. in designing skin replacements, the goal has been to re-create this model and make a product which has both essential components. methods: in the present study, we developed procedures for establishing confluent, stratified layers of cultured human keratinocytes on the surface of modified collagen-chito...

OBJECTIVES Open fractures with bone loss are common, disabling injuries. Biodegradable, load-bearing scaffolds able to carry high concentrations of local antibiotics are an emerging technology to address these injuries. This study investigates the use of such scaffolds with gentamicin (along with bone morphogenetic protein) in an infected rat open fracture model to decrease osteomyelitis and pr...

Background: Extensive full-thickness burns require replacement of both epidermis and dermis. In designing skin replacements, the goal has been to re-create this model and make a product which has both essential components. Methods: In the present study, we developed procedures for establishing confluent, stratified layers of cultured human keratinocytes on the surface of modified collagen-chito...

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Laura Elomaa Name of the doctoral dissertation Synthesis of biodegradable photocrosslinkable polymers for stereolithography-based 3D fabrication of tissue engineering scaffolds and hydrogels Publisher School of Chemical Technology Unit Department of Biotechnology and Chemical Technology Series Aalto University publication seri...

Compared with traditional in-vitro cell culture materials, three-dimensional nanofibrous scaffolds provide a superior environment for promoting cell functions. Since nanofibrous scaffolds have nanometer pore sizes, cells are unable to penetrate on their own, so must be incorporated into the scaffold during fabrication to ensure proper cell distribution. In this study, biodegradable and cytocomp...

INTRODUCTION The aim of this study was to evaluate the outcome of Osteoplug, a novel biodegradable polymer burr-hole cover implant, used in patients with burr holes done for drainage of chronic subdural haematoma. METHODS 12 patients with chronic subdural haematoma had Osteoplug implants inserted into their burr holes after evacuation of the haematoma. Osteoplug is a biodegradable polycaprola...

current treatments using nondegradable fi xation materials have proven effi cacious, tissueengineering approaches with biodegradable implants are being considered as promising future alternatives [8, 49]. One possible advantage of these systems is that biodegradable implants can be engineered to provide temporary support for bone fractures, and because they can degrade at a rate matching new ti...