In this paper, we investigate the application of an unsupervised extension of the recently proposed k–windows clustering algorithm on gene expression microarray data. The k–windows algorithm is used both to identify sets of genes according to their expression in a set of samples, and to cluster samples into homogeneous groups. Experimental results and comparisons indicate that this is a promisi...

• R. Durbin, S. Eddy, A. Krogh und G. Mitchison, Biological sequence analysis, Cambridge, 1998 • D.W. Mount. Bioinformatics: Sequences and Genome analysis, 2001. • V. Bafna, S. Muthukrishnan, R. Ravi, Computing similarity between RNA strings. • D. Sankoff, Simultaneous solution of the RNA Folding , Alignment and Protosequence Problems, SIAM Journal of Appl. Math., 45,5,1985 • J. Gorodkin, L.J. ...

MOTIVATION Improving the usability of bioinformatics resources enables researchers to find, interact with, share, compare and manipulate important information more effectively and efficiently. It thus enables researchers to gain improved insights into biological processes with the potential, ultimately, of yielding new scientific results. Usability 'barriers' can pose significant obstacles to a...

Over the past few years, the analysis of alternative splicing using bioinformatics has emerged as an important new field, and has significantly changed our view of genome function. One exciting front has been the analysis of microarray data to measure alternative splicing genome-wide. Pioneering studies of both human and mouse data have produced algorithms for discerning evidence of alternative...

Authors of papers to the bioinformatics approach tbo analyse the nucleotide and amino acid sequence of alpha synuclein nucleotide and amino acid. including as the character of physical and hydrophobicity, seondary structure prediction domains, prediction of the conserved domains and phylogenetic analysis. The results showed the α-synuclein encode a deduced 1462amino acid, had a predicted molecu...

The advent of cheaper, faster sequencing technologies has pushed the task of sequence annotation from the exclusive domain of large-scale multi-national sequencing projects to that of research laboratories and small consortia. The bioinformatics burden placed on these laboratories, some with very little programming experience can be daunting. Fortunately, there exist software libraries and pipe...

Genomes follow laws resembling celestial orbits. In a recent publication on Nature Scientific Reports[1] two computer scientists (V. Manca and V. Bonnici) discovered strong mathematical regularities in the structure of genomes. These regularities can be expressed in terms of simple laws based on ellipses, hyperbolas and parabolas. But the geometrical forms do not cope with spatial movements, ra...

Using gene expression data for cancer detection is one of the famous research topics in bioinformatics. Theoretically, gene expression data is capable to detect all types of early cancer development in molecular level. Traditional clustering and pattern mining algorithm are either inadequate to handle high dimensional gene expression data effectively or the results obtained are not easy to unde...

Protein analysis in dissolved organic matter: what free proteins from soil leachate and surface water can tell us – a perspective W. Schulze Center for Experimental Bioinformatics, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark Received: 15 November 2004 – Accepted: 13 December 2004 – Published: 20 December 2004 Correspondence to: W. Schulze ([email protected]) © 2004 Auth...