OBJECTIVE Low-dose-rate (LDR) brachytherapy is an effective treatment for tongue cancer. However, little is known about the biological mechanism underlying this therapy, characterized by delivery of continuous exposures of LDR irradiation. It is reported that lower microvessel density (MVD), lower Ki-67 index or higher expression of endogenous hypoxic markers such as carbonic CA IX and Glut-1 a...

High-throughput sequencing has revolutionized the field of biological sequence analysis. Its application has enabled researchers to address important biological questions, often for the first time. This book provides an integrated presentation of the fundamental algorithms and data structures that power modern sequence analysis workflows. The topics covered range from the foundations of biologi...

UNLABELLED The analysis of biological networks has become essential to study functional genomic data. Compadre is a tool to estimate pathway/gene sets activity indexes using sub-matrix decompositions for biological networks analyses. The Compadre pipeline also includes one of the direct uses of activity indexes to detect altered gene sets. For this, the gene expression sub-matrix of a gene set ...

Understanding the evolution characteristics and driving mechanisms of eutrophic lake ecosystems, especially over long time scales, remains a challenge. Little research on ecosystem mutation has been conducted using long-term series data. In this study, water quality indicators, as well ecological indexes, natural meteorological factors, socio-economic were collected for Tai Lake to enable us st...

iv 1 Components of Reliability and U 1 2 Relative Utility Index Ur for Composite Scores 4 3 Estimating Ur for Raw Scores and Ũr for Scale Scores 5 3.1 Raw Scores . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.2 Scale Scores . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.2.1 Variance of T ̃ . . . . . . . . . . . . . . . . . . . . . . . . 6 X 3.2.2 Covariance of T...

This paper studies a general notion of flatness in the enriched context: P-flatness where the parameter P stands for a class of presheaves. One obtains a completion of a category A by considering the category F latP(A) of P-flat presheaves over A. This completion is related to the free cocompletion under a class of colimits defined by Kelly. We define a notion of Q-accessible categories for a f...