We find an expression for the Gateaux derivative of C⁎-algebra norm. Using this, we obtain a characterization orthogonality operator A∈B(H,K) to subspace, under assumption dist(A,K(H,K))<‖A‖. subdifferential set norm function at A∈B(H) when dist(A,K(H))<‖A‖. also give new proofs known results on closely related notions smooth points and Birkhoff-James spaces B(H) Cb(Ω), respectively.