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Abstract Background and Aims: To identify and isolation of viruses a susceptible cell is need which can be primary or line. The use of primary cells is laborious, time consuming and expensive, while the use of cell lines is much easier and faster. IRKHBK cell line was originated from primary cells of bovine kidney by continuous passage. The aim of this study was to introduce the IRKHBK cell ...

BK polyomavirus infection is the important cause of virus-related nephropathy following kidney transplantation. BK virus reactivates in 30%-80% of kidney transplant recipients resulting in BK virus-related nephropathy in 1%-10% of cases. Currently, the molecular processes associated with asymptomatic infections in transplant patients infected with BK virus remain unclear. In this study we evalu...

BK virus infection is a challenging complication in renal allograft recipients and has been associated with hematuria, ureteral stenosis, nephropathy and malignancy. BK virus infection occurs early during childhood and the virus lays dormant in uroepithelial cells. Reactivation of the virus in renal transplant recipients is particularly worrisome because of its propensity to cause local damage ...

Urine cytology often is used to identify BK virus in kidney transplant recipients in the cytology laboratory. To assess the usefulness of the shell vial cell culture assay to identify BK virus, urine samples from 42 kidney transplant recipients were tested by the urine cytology and shell vial cell culture assays. The shell vial cell culture assay is just as sensitive and specific as urine cytol...

Polyomavirus-associated nephropathy in kidney transplantation is viewed as a complication of prolonged, intense immunosuppression, which disrupts the balance between antiviral immune control and polyomavirus replication. The prevalence rate ranges from 1-10% in kidney transplant programs around the world, with graft failure and return to dialysis in > 50%. Most cases are caused by the human pol...