Both clinical and basic problems related to the congenital bleeding disorders continue to confront hematologists. On the forefront are efforts to bring genetic correction of the more common bleeding disorders such as hemophilia A to the clinic in a safe and accessible manner. A second issue, particularly for patients with hemophilia, is the development of inhibitors-questions of how they arise ...

Patients with known coagulation deficiencies, either congenital or acquired, may bleed spontaneously with trauma or with surgical intervention. In contrast, however, are the unchallenged patients who bleed in a variety of clinical settings that demand rapid diagnosis so that appropriate therapy can be instituted. In the first section Dr. Louis M. Aledort demonstrates a series of vignettes of ac...

Dental health care workers are increasingly called upon to provide quality dental care to individuals whose bleeding and clotting mechanisms have been altered by inherited or acquired diseases. This provides an opportunity for the dentist who is trained in the recognition of oral and systemic signs of altered hemostasis to assist in the diagnosis of the underlying condition. A number of dental ...

more than 65 years old, and the use of antiplatelet agents is vastly more common than that. Patients with inherited bleeding disorders will likely present to the emergency department (ED) for treatment of abnormal bleeding at some point during their lifetime, and ED visits for bleeding in patients who are taking antithrombotic agents are not uncommon. The clinician must be familiar with these d...

Genetic bleeding disorders form an important presentation among various genetic disorders occurring in children. A prevalence of 6 per 100,000 population has been reported in India. Bleeding disorders constitute a heterogenous group of disorders with varying clinical presentations. The common bleeding disorders are Hemophilia A and B, von Willebrand disease, and inherited thrombocytopenias. In ...

Bleeding disorders and thromboembolic diseases represent abnormalities of the hemostatic mechanism. As this mechanism is basically a defense device against the loss of blood from the vascular system, any serious breakdown can bring about life-threatening hemorrhages. The author describes the inherent problems involved in these cases; and since many of the recognized congenital and acquired blee...

sons, except in a limited role of reference for a specific topic. It is an excellent book for the biologist, particularly the aquatic biologist, and is highly recommended for their general use. In addition it is a fine reference for those concerned with developing, establishing, and planning programs of water pollution control. It is unfortunate that the word "control" has been used in the titl...