BACKGROUND Immunofluorescence testing is an important tool for diagnosing blistering diseases. OBJECTIVE To characterize the immunofluorescence findings in patients diagnosed with autoimmune blistering skin diseases. METHODS We retrospectively analyzed immunofluorescence results encompassing a 10-year period. RESULTS 421 patients were included and divided into 2 groups: group 1- intraepid...

Dermatitis herpetiformis (DH) is an autoimmune blistering skin disorder that is associated with gluten sensitivity. It presents as a papulovesicular rash and is often associated with enteropathy. The rash resolves when the patient is placed on a gluten-free diet and/or dapsone. DH, as well as celiac disease, is tightly associated with DQ2 and DQ8. A novel mouse model for DH is described that ut...

Epidermolysis bullosa acquisita (EBA) is an acquired blistering skin disease characterized by the presence of IgG autoantibodies that recognize type VII (anchoring fibril) collagen. In this study, we have mapped the antigenic epitopes within the type VII collagen alpha chain by Western immunoblotting analysis with sera from 19 patients with EBA, using bacterial collagenase- or pepsin-resistant ...

Summary Pemphigus vulgaris (PV) is an autoimmune blistering disease produced by IgG autoantibodies against desmoglein (Dsg)3. Lesions on the skin and mucosa can, in rare cases, be induced by radiotherapy. We report a patient with a history of microprolactinoma and PV, who had only oral lesions from the beginning of her illness but 2 months after treatment with radiotherapy for a breast neoplasi...

Surgical wounds generally heal by primary intention with few complications (Ousey et al, 2011). However, certain patient factors and surgical types may predispose postoperative incisions to skin blistering, particularly if an unsuitable postoperative wound dressing is used. Skin blistering occurs when the epidermis becomes separated from the dermis and results from continued friction on the ski...

We describe a case of 5-year-old boy who presented with multiple mild itchy and painful blisters predominantly over his trunk limbs for one year tense bullae hypopyon signs resulting in half-and-half appearance the blisters. A skin biopsy showed subepidermal separation neutrophils eosinophils bulla cavity mixed infiltrate papillary dermis. would like to report chronic bullous disease childhood ...