Vitamins k is an important fat-soluble vitamin that can be obtained from plants, bacteria and animals necessary for the blood clotting. It plays a key function as cofactor in synthesizing of clotting proteins liver; recently, interest its functions extra-hepatic tissue has increased. Vitamin deficiency usually caused by abnormal absorption rather than lack food. Apart impact on clotting, chroni...

Objective(s):  Titanium oxides are known to be appropriate hemocompatible materials which are suggested as coatings for blood-contacting devices. Little is known about the influence of nanometric crystal structure, layer thickness, and semiconducting characteristics of TiO2 on blood hemostasis.   Materials and Methods: Having used sol-gel dip coating method in this study, TiO2 thin films were d...

The topic of this thesis is the simulation of blood clotting using the Lattice Boltzmann method and taking into account the non-Newtonian behavior of blood. This kind of simulations could be used for the treatment of diseases like stenosis and aneurysms. Their field of application includes the diagnostic of the diseases, the planning of surgeries and the investigation of new medical treatment s...

The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally. The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4±0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, fema...

The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations (which can be written as differential equations) and the latter comprise both threshold-limited behaviors and qualitative facets of the coagulation cascade. We model this proces...

conclusions an hb-driven algorithm, in combination with the “coagulation box” and the early use of clotting factors, could be a simple and effective tool for improving coagulopathy in multiple trauma patients. results over a 12-month investigation period, 123 severe multiple trauma patients needing intensive care therapy were admitted to our trauma center (mean age 48 years, mean iss (injury se...

Evidence for the involvement of the sixth component of complement (C6) in normal blood coagulation is provided by the description of a coagulation abnormality in rabbits with a genetic C6 deficiency and by its correction with highly purified preparations of C6. Whole blood clotting time in glass or plastic was prolonged and prothrombin consumption was decreased in blood from the deficient anima...