E5531, a novel synthetic lipid A analogue, antagonizes the toxic effects of lipopolysaccharide, making it a potential intravenously administered therapeutic agent for the treatment of sepsis. This report describes the distribution of E5531 in human blood and its activity when it is associated with different lipoprotein subclasses. After in vitro incubation of [(14)C]E5531 with blood, the great ...

The relationship between physical activity and blood lipids and lipoproteins in dialysis patients is reviewed in the context of the potentially confounding factors such as nutritional intake, cigarette smoking, obesity, alcohol intake, and physical activity levels in the general population and additional confounding factors such as mode of dialysis and diabetes in dialysis patients. The known a...

introduction atherosclerosis is a disease which begins during childhood. oxidation of lipoproteins is an important factor implicated in atherosclerosis. vitamin c decreases blood serum lipids and may inhibit atherosclerosis. this study was designed to observe the effect of ascorbic acid on blood serum lipids in male rabbits fed high-cholesterol diet. methods twenty white male rabbits were weigh...

To reveal the presence of atherogenic potential in the blood serum obtained from patients with angiographically assessed coronary atherosclerosis we used primary cultures of subendothelial cells isolated by collagenase from unaffected human aortic intima. Earlier, we have demonstrated that such cultures are made up mostly of typical and modified smooth muscle cells. Within 24 hours of cultivati...

type 2 diabetes mellitus (t2dm) occurs around the world with high prevalence and causes serious physical harm and economic burden to the afflicted. haikou city is china's southernmost tropical island city, which has not been previously studied for its t2dm prevalence. the objective of the study in employing a cross-sectional survey is to discuss the epidemiologic status of t2dm in haikou city a...

Carbon tetralchloride was injected into normnal rabbits and the levels of Sf 3-12, 12-20, alnd(20-40 lasses of lipoproteins were determined during the course of these injections. A marked increase in concentration of these three classes of lipoproteins occurred during the administration of carl)on tetra(hloride. After the cessation of this drug, the lipoproteins of largest Sf rate returned to n...

The features of the vasoregulating function vascular endothelium have been determined and correlations between haemodynamic metabolic indices established in patients with coronary heart disease associated type II diabetes mellitus. In mellitus comparison without an association significantly higher content blood fibrinogen diameter brachial artery (after decompression) were observed. Direct fast...

The morphology of red blood cells was studied in 30 patients with severe liver cirrhosis, in 10 patients with extrahepatic jaundice, and in 10 control subjects. In all the patients with extrahepatic jaundice more than 30% of red blood cells were target cells with increased resistance to osmotic lysis. In 12 patients with liver cirrhosis more than 30% of red blood cells were spur cells. The chol...