The malaria parasite Plasmodium falciparum is a complex eukaryote parasite with a dynamic pattern of genomic expression, enabling it to exploit a series of different habitats in human and mosquito hosts. In the human bloodstream, the parasite grows and multiplies within red blood cells and modifies them in various ways to gain nutrients and combat the host's defences, before escaping and invadi...

The effect of a recombinant hybrid human interferon alpha (IFN-alpha) (which cross-reacts with murine cells) on C57BL/6 mice infected with Plasmodium yoelii sporozoites or parasitized erythrocytes was determined. IFN-alpha did not inhibit the development of the parasite in the liver, but it did reduce the blood parasite load and the hepatosplenomegaly induced by the infection in mice injected w...

The best correlate of malaria severity in human Plasmodium falciparum (Pf) infection is the total parasite load. Pf-infected humans could control parasite loads by two mechanisms, either decreasing parasite multiplication, or increasing parasite clearance. However, few studies have directly measured these two mechanisms in vivo. Here, we have directly quantified host clearance of parasites duri...

Host–parasite dynamics often vary over time, brought about by changes in the parasite’s virulence or host’s ability to resist tolerate parasite. Although evolution microparasites is well studied, we know little temporal change pathogenicity of macroparasites such as blood-feeding insects. Using data collected 35 yr, report a reduction hematophagous swallow bug (Cimex vicarius) on its Cliff Swal...

This paper investigates the possibility of computerised diagnosis of malaria and describes a method to detect malaria parasites (Plasmodium spp) in images acquired from Giemsa-stained peripheral blood samples under conventional light microscopes. Prior to processing, the images are transformed to match a reference image colour characteristics. The parasite detector utilises a Bayesian pixel cla...

Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vaccinated mice developed a patent infection after challenge similar to that obse...

background: this study was conducted to collect informative data on the parasitic infection of wild rodents, emphasizing on finding parasites, which have medical importance to human. methods:   during 2012-2014, a total number of 91 wild rodents were captured from rural areas of turkmen sahra, golestan province, using handmade traps. animals were anesthetized, surveyed for any ectoparasite and ...

Blood feeding is an integral process required for physiological functions and propagation of the malaria vector Anopheles. During blood feeding, presence of the malaria parasite, Plasmodium in the blood induces several host effector molecules including microRNAs which play important roles in the development and maturation of the parasite within the mosquito. The present study was undertaken to ...

is to be considered bad medicine, for only a "'action of these patients have malaria and need quinine. In the present shortage of quinine, such a practice is to be utterly condemned as Evolving a tragic waste of quinine. While thorough clinical examination, including ? careful history, will usually give a strong Judication whether or not the patient with lever ' has malaria, with modern methods...