STUDY OBJECTIVES To verify whether and to what extent the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index correlates with a disease-specific index of health status in patients with COPD. DESIGN Cross-sectional study. SETTING University-affiliated hospital. PATIENTS One hundred patients with stable COPD recruited from the outpatient clinic of a single inst...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity in the elderly population. COPD leads to a reduced health-related quality of life (HRQL), but the factors which contribute to this are not well understood. A better understanding of the factors which determine HRQL should lead to an improved care for such patients. OBJECTIVES The purpose of this study was to...

and commentary also appear in ACP Journal Club. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . For correspondence: Dr B R Celli, St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, MA, USA. [email protected] Source of funding: no external funding. BODE index for predicting death in chronic obstr...

Chronic obstructive pulmonary disease (COPD) is defined by persistent airflow limitation that is usually progressive [1], and its severity has long been classified using forced expiratory volume in 1 s (FEV1) % predicted. Although levels of FEV1 were often reported to predict mortality, the observation that other pulmonary and extrapulmonary variables also predicted mortality led to the develop...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is not only characterized by chronic airflow limitation, but is also a systemic disease. There is no information about alterations in right ventricle (RV) functions precipitated by systemic manifestations of COPD. OBJECTIVES We aimed to evaluate the relationship between the BODE (body mass index, airflow obstruction, dyspnea, and exercis...

BACKGROUND High sensitive CRP (hs-CRP) is used as a marker of systemic inflammation in chronic obstructive pulmonary disease (COPD). However, we hypothesize that the raised hs-CRP is not closely related to the multiple consequences of COPD. This study was undertaken to investigate the association of COPD assessment test (CAT) score with SpO2, FEV1, body mass index (BMI), obstruction, dyspnea an...

Health-related quality of life (HRQOL) scales are tools of great interest in chronic obstructive pulmonary disease (COPD). While currently available therapeutic measures do not noticeably improve lung function parameters, they can lead to an improvement of symptoms refl ected in patient quality of life. HRQOL scales could therefore be used to justify a particular treatment even in the absence o...

background: depression and smoking decrease health status in chronic obstructive pulmonary disease (copd), but the combined effect of the two factors is unknown. this study aimed to assess the interactive effects of depression and smoking on the severity of patients with copd. methods: a prospective cohort study including 2,268 patients with copd was conducted in seven rural communities from ma...

INTRODUCTION Both BODE score (body mass index, degree of airflow obstruction, functional dyspnea, and exercise capacity) and serum C-reactive protein (CRP) are validated predictors of mortality in patients with chronic obstructive pulmonary disease (COPD). The aim of this study is to investigate the predictive value of combined serum CRP and BODE score for mortality in COPD patients. PATIENTS...

The value and timing of multidimensional assessments in chronic obstructive pulmonary disease (COPD) remains unclear because there is little information about their variability and relationship to outcome. The aim of this study was to determine the progression of COPD using clinical and spirometric variability over time with mortality as the outcome. We determined the annual intra-individual va...