Shiramizu K; Lovric V; Leung AMD; +Walsh WR Surgical & Orthopaedic Research Laboratories, University of New South Wales, Sydney, Australia [email protected] INTRODUCTION Deep infection after total joint replacement is a severe complication, and the use of antibiotic-loaded bone cement as a joint spacer is an established and efficient treatment method to treat infected arthroplasties. When pre...

The use of polymethylmethacrylate (PMMA) cement to reinforce fragile or broken vertebral bodies (vertebroplasty) leads to extensive bone stiffening. This might be one reason for fractures at the adjacent vertebrae following this procedure. PMMA with a reduced Young's modulus may be more suitable. The goal of this study was to produce and characterize PMMA bone cements with a reduced Young's mod...

BACKGROUND Polymethylmethacrylate bone cement cannot provide an adhesive chemical bonding to form a stable cement-bone interface. Bioactive bone cements show bone bonding ability, but their clinical application is limited because bone resorption is observed after implantation. Porous polymethylmethacrylate can be achieved with the addition of carboxymethylcellulose, alginate and gelatin micropa...

Loosening of total joint replacements may be caused in part by thermal necrosis of bone in contact with the high temperature of the polymerizing PMMA acrylic cement. This study reports a method to reduce the temperature of the bone-cement interface below the temperature at which bone results in definite necrosis. By precooling the acetubular component to --84 degrees before insertion into the c...

BACKGROUND Cement spacers (Masquelet technique) have traditionally been used for the treatment of segmental bone defects. However, no reports have used cement spacers for the treatment of small/partial segmental bone defects associated with osteomyelitis and compared the outcomes with cement beads. METHODS We retrospectively analysed 40 patients with post-traumatic osteomyelitis of the tibia ...

The initial composition of acrylic bone cement along with the mixing and delivery technique used can influence its final properties and therefore its clinical success in vivo. The polymerisation of acrylic bone cement is complex with a number of processes happening simultaneously. Acrylic bone cement mixing and delivery systems have undergone several design changes in their advancement, althoug...

Use of antibiotic-loaded bone cement for prophylaxis against infection is not indicated for patients not at high risk for infection who are undergoing routine primary or revision joint replacement with cement. The mechanical and elution properties of commercially available premixed antibiotic-loaded bone-cement products are superior to those of hand-mixed preparations. Use of commercially avail...

Even though antibiotic eluting bone cements are successfully used in orthopedic practice, adding chemotherapy drugs to bone cement pose a different set of problems. This is mainly due to the toxicity concerns associated with the use of chemotherapy agents. To avoid local or systemic toxicity, the drug elution profile of a particular bone cement/drug concentration need to be determined. The drug...

In the last years, several methods have been used to enhance bone repair and new bone formation. Numerous researches have been focused on possibilities of healing bone defect by using biomaterial implants. Clay cement may represent an important bone substitute and could be used for the treatment of multiple fractures and after bone tumor resection. The aim of this study is to investigate biocom...

We have developed a bioactive bone cement (BA cement) consisting of Bis-GMA resin and bioactive glass powder. It has high compressive and tensile strengths, a low curing temperature and its bioactivity allows it to bond directly with bone. We operated on the 18 femora of nine mongrel dogs for intercalary replacement of part of the bone by a metal prosthesis using either PMMA cement or BA cement...