Overweight and obesity are rapidly expanding health problems in children and adolescents. Obesity is associated with greater bone mineral content that might be expected to protect against fracture, which has been observed in adults. Paradoxically, however, the incidence of bone fractures has been found to increase in overweight and obese children and adolescents. Prior studies have shown some r...

Bone mineral density [BMD] generally correlates with bone strength. BMD testing is used to assess bone density and diagnose osteoporosis. The correlation between CT numbers and mechanical property estimated from cortical bone were found to be low (r2<0.2) and cancellous bone were found to be higher (r2>0.6). The specific relationship depending on the types of bone, that predict elastic module f...

BACKGROUND Alendronate can induce esophagitis and stomach ulceration requiring the concurrent use of drugs which decrease HCl production. The aim of the present study was to investigate the effect of concurrent administration of proton pump inhibitors, omeprazole or pantoprazole, and alendronate on the mechanical properties of long bones in bilaterally ovariectomized (OVX) rats. METHODS The e...

Initiated and motivated by clinical and scientific problems such as age-related bone fracture, prosthetic loosening, bone remodeling, and degenerative bone diseases, much significant research on the properties of trabecular bone has been carried out over the last two decades. This work has mainly focused on the central vertebral trabecular bone, while little is known about age-related changes i...

Trabecular bone is a highly porous, heterogeneous, and anisotropic material which can be found at the epiphyses of long bones and in the vertebral bodies. Studying the mechanical properties of trabecular bone is important, since trabecular bone is the main load bearing bone in vertebral bodies and also transfers the load from joints to the compact bone of the cortex of long bones. This review a...

In this study, mechanical properties and apatite formation ability of synthesized fluorapatite-hardystonite (FA-HT) nanocomposite scaffolds were investigated. Hardystonite (HT; 5 and 10 wt.%) as a reinforcement phase was incorporated into the FA scaffold. FA was mixed with HT for 4 h under argon gas at 220 °C. A space holder method was used for fabricating porous FA-HT scaffolds. Sodium chlorid...

INTRODUCTION During maturation bone undergoes changes in its composition, organization and mechanical properties [1-2]. However, the contribution of the collagen framework on the properties of maturing bone is not well understood. Previous studies in mice and horses showed that the collagen network experiences significant structural modifications during development and maturation [2-3]. Our obj...

INTRODUCTION: Synthetic calcium phosphate cements (CPC) which mimic the chemical structure of the mineral composition of bone have been well accepted as bone grafting materials due to their consistent osteoconductivity, ease of use, and mechanical properties but are limited in application due to their lack of osteoinductive potential. Demineralized Bone Matrix (DBM) has also found significant a...

The increase of patients with osteoporosis is a social problem. Osteoporosis decreases bone strength and increases the risk of fracture. The finding of prevention and treatment methods is an urgent issue. Since cancellous bone is metabolically more active than cortical bone, cancellous bone is used for diagnosis of osteoporosis. There are a lot of studies about stress analysis of cancellous bon...