نتایج جستجو برای: bone sialoprotein
تعداد نتایج: 305372 فیلتر نتایج به سال:
To explore how the loss of Phex function contributes to the pathogenesis of osteomalacia, we examined the abnormalities of mineralization, Phex, and bone matrix protein expression occurring in Hyp mice in vivo and in ex vivo bone marrow cell cultures. The results in vivo show that mineralization was decreased significantly in Hyp mouse bone. Phex protein was identifiable in osteoblasts and oste...
INTRODUCTION The major focus of this study is the elucidation of the molecular mechanisms that regulate bone sialoprotein (BSP) expression. BSP is one of the major non-collagenous proteins (NCP's) synthesized by bone cells and like osteocalcin is the only other known NCP which has a restricted expression to mineralized skeletal tissues (1,2). BSP is an RGD containing phosphorylated sialoprotein...
We isolated cells from both calvaria and the outer cortices of long bones from 3- to 5-mo bovine fetuses. The cells were identified as functional osteoblasts by indirect immunofluorescence using antibodies against three bone-specific, noncollagenous matrix proteins (osteonectin, the bone proteoglycan, and the bone sialoprotein) and against type 1 collagen. In separate experiments, confluent cul...
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