PurposeLong-term survival after lung transplantation (LT) is hampered by the occurrence of chronic allograft dysfunction (CLAD). CLAD may manifest as bronchiolitis obliterans syndrome (BOS) or restrictive (RAS), and triggered several factors, e.g. post-transplant infections. As immunoglobulin (Ig) A crucial to ensure mucosal immunity limit airway microbial load, we explored whether IgA its epit...

BACKGROUND Bronchiolitis obliterans syndrome (BOS) is delayed allograft deterioration after lung transplant (LTX) that is clinically characterized by ≥ 20% decline from the baseline value of forced expiratory volume during the first second (FEV1). BOS is still a major obstacle limiting long-term survival post-LTX. The main aim of this study was to determine the predictors of BOS and death in Ir...

BACKGROUND Chronic lung allograft dysfunction in the form of bronchiolitis obliterans syndrome (BOS) is the main cause of death beyond 1-year post-lung transplantation. The disease-initiating triggers as well as the molecular changes leading to fibrotic alterations in the transplanted lung are largely unknown. The aim of this study was to identify potential early changes in the extracellular ma...

The main change seen with BOS is scarring of the small airways of transplanted lung(s). This scarring leads to narrowing of the airways, limiting airflow with loss of lung function. Early after the onset of BOS, a person may not have any symptoms, but will develop breathlessness and chronic cough as BOS gets worse. There are different stages of BOS based on lung function results. Some people de...

34 35 Background: Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation 36 that is associated with poor survival. 37 38 Purpose: The American Thoracic Society (ATS), International Society for Heart and Lung 39 Transplantation (ISHLT), and European Respiratory Society (ERS) convened a committee of 40 international experts to describe and/or provide recommendatio...

In the current review the main fundamental biological differences in reproductive function between Bos taurus and Bos indicus cattle are discussed. Breed differences regarding puberty, estrous cycle patterns, estrous behavior, acquisition of ovulatory capacity, ovarian structures and reproductive hormones are presented. The main physiological differences that Bos indicus cattle present relative...

Bronchiolitis obliterans syndrome (BOS) is the main and late chronic complication after lung transplantation. It remains a major impediment to long-term outcome. Unfortunately, the survival rate of lung transplant recipients lags behind that of other organ transplant recipients, and BOS accounts for more than 30% of all mortality after the third year following lung transplantation. Most recent ...

STUDY OBJECTIVE To assess the potential utility of specific airway conductance (sGaw) in detecting small airways dysfunction, the postlung-transplant bronchiolitis obliterans syndrome (BOS) was used as a model of small airways dysfunction. BOS is defined as an otherwise unexplained 20% reduction in FEV1. We hypothesized that if sGaw is sensitive to small airways dysfunction, it should decrease ...

Auditory neurons of the anterior forebrain (AF) of zebra finches become selective for song during song learning. In adults, these neurons respond more to the bird's own song (BOS) than to the songs of other zebra finches (conspecifics) or BOS played in reverse. In contrast, AF neurons from young birds (30 d) respond equally well to all song stimuli. AF selectivity develops rapidly during song l...

Pemphigus vulgaris (PV) is a rare, potentially fatal, autoimmune disease that affects the skin and mucous membranes. The PV antigen (PVA) has been characterized as desmoglein 3. PV patients carry HLA-DR4- or HLA-DR6-bearing extended haplotypes. We recently demonstrated that patients with active disease have high titers of PV autoantibodies of the IgG1 and IgG4 subclasses. Patients in remission,...