SNEDDS merupakan campuran isotropik yang terdiri dari obat, surfaktan, ko-surfaktan dan minyak. Pengembangan optimasi formulasi tepat diperlukan untuk meminimalisir waktu, biaya, serta menjamin optimal. Tujuan penulisan artikel ini adalah menjelaskan aplikasi simplex lattice design (SLD) box behnken (BBD) dalam SNEDDS. Metode digunakan menyusun review yaitu teknik studi pustaka dengan mencari l...

Current research has been done to develop statistically and optimized immediate release tablets for eslicarbazepine. Nineteen formulations of eslicarbazepine acetate are prepared by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed study how selected independent variables affect dependent responses. After the initial test, items were as follows; polyvi...

Nanoliposomes are bilayer phospholipid vesicles used to encapsulate and deliver therapeutic agents. The study was aimed investigate the effects of critical variables on nanoliposomes characteristics. Imatinib mesylate-loaded were formulated by two-step emulsification process using a high-speed homogenizer system probe-type ultrasonicator. Box-Behnken design utilized optimize parameters. mean pa...

Alkaline lipase production by mutant strain of Pseudomonas aeruginosa MTCC 10,055 was optimized in shake flask batch fermentation using response surface methodology. An empirical model was developed through Box-Behnken experimental design to describe the relationship among tested variables (pH, temperature, castor oil, starch and triton-X-100). The second-order quadratic model determined the op...