نتایج جستجو برای: brainderived neurotrophic factor
تعداد نتایج: 846248 فیلتر نتایج به سال:
Conserved dopamine neurotrophic factor protects and rescues dopaminergic neurodegeneration induced by 6-hydroxydopamine in vivo, but its potential value in treating Parkinson's disease remains controversial. Here, we used the proteasome inhibitors lactacystin and MG132 to induce neurodegeneration of PC12 cells. Afterwards, conserved dopamine neurotrophic factor was administrated as a therapeuti...
BACKGROUND Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. METHODS Twenty-seven patients were started on agomelatine (25mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels w...
Peripheral nerve injury markedly regulates expression of neurotrophins and their receptors in the lesioned nerve. However, the role of endogenously produced neurotrophins in the process of nerve regeneration is unclear. Expression of a multifunctional neurotrophin, panneurotrophin-1 (PNT-1), was targeted to the peripheral nerves of transgenic mice by using a gene promoter that is specifically a...
Allergic asthma is a chronic inflammatory disease characterized by the production of allergenspecific IgE antibodies, TH2 inflammation, airway hyperresponsiveness and airway remodeling. Airway remodeling represents the diseaselimiting stage during disease progression, and the underlying cellular molecular network resulting in airway remodeling are still poorly defined. In addition to the welles...
Background: Previous evidence of gene-by-environment interactions associated with emotional and behavioral disorders is contradictory. Differences in findings may result from variation in valence and dose of the environmental factor, and/ or failure to take account of gene-by-gene interactions. The present study investigated interactions between the brainderived neurotrophic factor gene (BDNF V...
Cai, Dongqing, Jacquelyne M. Holm, Inga J. Duignan, Jingang Zheng, Munira Xaymardan, Andrew Chin, Victoria L. T. Ballard, Jonathan N. Bella, and Jay M. Edelberg. BDNF-mediated enhancement of inflammation and injury in the aging heart. Physiol Genomics 24: 191–197, 2006. First published December 13, 2005; doi:10.1152/physiolgenomics.00165.2005.—Aging is associated with shifts in autocrine and pa...
BACKGROUND Low circulating brain derived neurotrophic factor may promote cognitive deterioration, but the effects of neurotrophic and combination drug therapies on serum brain derived neurotrophic factor were not previously investigated in Alzheimer's disease. METHODS We evaluated the effects of Cerebrolysin, donepezil, and the combined therapy on brain derived neurotrophic factor serum level...
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