نتایج جستجو برای: brb

تعداد نتایج: 533  

Journal: :Molecular medicine reports 2015
Fenglan Zhang Xuejing Man Huajun Yu Limei Liu Yuanbin Li

Previous studies have shown that escin possesses glucocorticoid (GC)‑like anti‑edematous and anti‑inflammatory effects. The present study was designed to investigate whether escin exhibits synergistic protective effects against blood‑retinal barrier (BRB) breakdown when combined with GC in an in vitro monolayer BRB model, based on retinal pigment epithelial (RPE) cells and human umbilical vein e...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1995
D A August S Halter D E Brenner

Centrilobular hepatocyte contribution to doxorubicin (DOX) metabolism and myelotoxicity was probed with bromobenzene (BRB), a known centrilobular hepatotoxin. New Zealand White rabbits were given DOX, 3 mg/kg i.v. After 4 weeks, the rabbits were pretreated i. p. with 2.6 ml/kg 40% solution of BRB in corn oil followed 72 h later with a 3-mg/kg dose of DOX. Pharmacokinetics of DOX after BRB pretr...

Journal: :journal of the iranian chemical research 0
aiyoub parchehbaf jadid department of applied chemistry, ardabil branch, islamic azad university, ardabil, iran leila zarefatin department of applied chemistry, ardabil branch, islamic azad university, ardabil, iran leila javadi department of applied chemistry, ardabil branch, islamic azad university, ardabil, iran

in this study, we present the work on the physicochemical interaction between the anti-cancer alkaloidberberine (brb) and dna with the purpose of designing drugs that interact more with dna. molecularmodeling on the complex formed between berberine and dna presented that this complex was undeniablyfully able of participating in the formation of a stable intercalation site. besides, the molecula...

Journal: :Cancer research 2006
Tong Chen Hyejeong Hwang Miranda E Rose Ronald G Nines Gary D Stoner

Our laboratory has used a rodent model of human esophageal squamous cell carcinoma to identify putative chemopreventive agents for this disease and to determine their mechanisms of action. In the present study, we treated F344 rats with the esophageal carcinogen, N-nitrosomethylbenzylamine (NMBA), thrice per week for 5 weeks. Beginning 1 week later, they were fed a synthetic diet containing 5% ...

2016
Phillip S. Coburn Brandt J. Wiskur Frederick C. Miller Austin L. LaGrow Roger A. Astley Michael H. Elliott Michelle C. Callegan

The blood-retinal barrier (BRB) functions to maintain the immune privilege of the eye, which is necessary for normal vision. The outer BRB is formed by tightly-associated retinal pigment epithelial (RPE) cells which limit transport within the retinal environment, maintaining retinal function and viability. Retinal microvascular complications and RPE dysfunction resulting from diabetes and diabe...

2015
D. Ashari M. Lane F. Gu

In this paper, the diagnosis of broken rotor bar (BRB) is investigated analytically and experimentally based on induction motors (IM) with variable speed drives (VSD). The analysis of the VSD process has understood that the sensorless control mode adjusts both supply voltage and current in order to maintain the operating speed within high accuracy. It means that any asymmetric problems with the...

Journal: :The Journal of clinical investigation 1993
S Santoso R Kalb M Walka V Kiefel C Mueller-Eckhardt P J Newman

The human GPIa/IIa complex, also known as integrin alpha 2 beta 1, serves as a major receptor for collagen in platelets and other cell types. In addition to its role in platelet adhesion to extracellular matrix, GPIa/IIa is also known to bear the clinically important Br(a) and Brb alloantigenic determinants, which can result in antibody-mediated platelet destruction. Immunochemical studies show...

Journal: :Journal of experimental botany 2007
Y Genc C Y Huang P Langridge

Zinc (Zn) deficiency reduces crop yields globally. This study investigated the importance of root morphological traits, especially root hairs, in plant growth and Zn uptake. Wild-type barley (Hordeum vulgare) Pallas and its root-hairless mutant brb were grown in soil and solution culture at different levels of Zn supply for 16 d. Root morphological traits (root length, diameter, and surface are...

Journal: :Diabetes 2014
Aldina Reis Catarina Mateus Pedro Melo João Figueira José Cunha-Vaz Miguel Castelo-Branco

It is unknown whether independent neural damage may occur in the pre-/absent vascular diabetic retinopathy (DR). To exclude vasculopathy, it is important to measure the integrity of the blood-retinal barrier (BRB). This cross-sectional study addressed this problem in type 1 diabetic patients with normal ocular fundus and absent breakdown of the BRB (confirmed with vitreous fluorometry). These w...

Journal: :Cancer prevention research 2014
Li-Shu Wang Carol A Burke Henrietta Hasson Chieh-Ti Kuo Christine L Sardo Molmenti Claire Seguin Pengyuan Liu Tim H-M Huang Wendy L Frankel Gary D Stoner

Familial adenomatous polyposis (FAP) is characterized by the early onset of colonic polyposis and a high risk for colorectal cancer. FAP is treated by colectomy followed by lifelong removal of rectal polyps. This study determined whether black raspberries (BRBs) might regress rectal polyps in patients with FAP. Fourteen patients with FAP were treated with BRBs daily for 9 months. Seven patients...

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