OBJECTIVES To compare bleeding patterns for 12 months continuous use of a contraceptive ring [contraceptive vaginal ring (CVR)] and pill [combined oral contraceptive (COC)] on a menstrually signaled regimen and the effectiveness of 4 days "treatment withdrawal" to stop bleeding. STUDY DESIGN Women, 66 to each group, were randomized to continuous use of a CVR (15 mcg ethinyl estradiol/150 mcg ...

Recent research has not been able to demonstrate close endometrial morphological correlations with specific abnormalities of menstrual bleeding, but has pointed to an increasing number of molecular mechanisms that may be involved in the occurrence of certain forms of abnormal uterine bleeding. Ovulatory and anovulatory dysfunctional uterine bleeding (DUB) and progestogen-related breakthrough bl...

and Femodene [1] standard strength combined oral contraceptive (gestodene 75 g þ ethinylestradiol 30 g) (combined oral contraceptive). Her arthritis improved with the methotrexate but she developed intermenstrual bleeding of bright red blood for 3 h after every methotrexate dose. She stopped the methotrexate for 2 weeks and bled again after rechallenge. Her normal withdrawal periods became heav...

Pain is one of the most common and often most feared symptoms in patients with cancer. Ongoing or progressive pain is physically debilitating and has a marked impact on quality of life. During their illness, at least 70% of patients will experience pain sufficiently severe to require chronic opioid treatment. Moreover, Breakthrough Pain (BTP) consists in transitory exacerbations of pain that oc...

Vacuum curettage was performed on 348 women who had received various regimens of oestrogen treatment for an average of 9.7 months for climacteric symptoms. In 62 cases (18%) the specimens were unsatisfactory for histological assessment; among the remainder, however, they showed a normal endometrium in 257 cases (90%), cystic hyperplasia in 21 (7%), adenomatous hyperplasia in 7 (2%), and endomet...

The use of antifibrinolytic agents in recent years had been heralded as a major breakthrough in the prevention of postoperative bleeding. However, whenever the delicate balance between coagulation and fibrinolysis is altered, the potential exists for disaster. There have been a number of complications reported in the literature related to the use of antifibrinolytics. With the availability of o...

BackgroundFor patients with atrial fibrillation (AF) having ischemic stroke or transient attack (TIA) despite taking direct oral anticoagulants (DOAC), the optimal strategy for ongoing anticoagulation is unknown.MethodsUsing provincial administrative databases in Alberta, Canada, we compared anticoagulant use before/after breakthrough stroke/TIA and assessed recurrence of bleeding, consideratio...