Background: Cancer is a heterogeneous disease encompassing various subtypes. Exploration of novel biomarkers important to tailor therapy. Aim: The main aim this study was toexplore the prognostic value soluble CD44 in sera breast cancer patients (BCPs), and correlate its levels with hyaluronic acid (HA), VEGF p53 levels. Subjects Methods: Fifty female BCPs were enrolled as patient group 50 heal...

We have previously reported hepcidin and ferritin increases in the plasma of breast cancer patients, but not in patients with benign breast disease. We hypothesized that these differences in systemic iron homeostasis may reflect alterations in different iron-related proteins also play a key biochemical and regulatory role in breast cancer. Thus, here we explored the expression of a bundle of mo...

Female breast cancer is one of the leading causes of female mortality worldwide. In Malaysia, breast cancer is the most commonly diagnosed cancer in women. Of the women in Malaysia, the Chinese have the highest number of breast cancer cases, followed by the Indian and the Malay. The most common type of breast cancer is infiltrating ductal carcinoma (IDC). A proteomic approach was applied in thi...

Breast cancer is the leading cause of cancer and mortality in women worldwide. Recent studies have argued that there is a close relationship between lipid synthesis and cancer progression because some enzymes related to lipid synthesis are overexpressed in breast cancer tissues. However, lipid distribution in breast cancer tissues has not been investigated. We aimed to visualize phosphatidylcho...

The paper presents the results for water confined in a human breast cancerous tissue, a single stranded DNA, a double stranded DNA and in phospholipids (DPPC—D--Phosphatidylcholine, dipalmitoyl). The interfacial water in DNA and lipids is represented by a double band in the region of the OH stretching mode of water corresponding to the symmetric and asymmetric vibrational modes, in contrast to...

objective: during the past decade, the importance of biomarker discovery has been highlighted in many aspects of cancer research. biomarkers may have a role in early detection of cancer, prognosis and survival evaluation as well as drug response. cancer-testis antigens (ctas) have gained attention as cancer biomarkers because of their expression in a wide variety of tumors and restricted expres...

Aberrant metabolism in breast cancer tumors has been widely studied by both targeted and untargeted analyses to characterize the affected metabolic pathways. In this work, we utilize ultra-performance liquid chromatography (UPLC) in tandem with ion mobility-mass spectrometry (IM-MS), which provides chromatographic, structural, and mass information, to characterize the aberrant metabolism associ...

Matrix metalloproteinase-13 (MMP-13) has a potential role in tumour invasion and metastasis. However, its relevance to the prognosis of human breast cancer is poorly understood. The aim of this study is to investigate the expression patterns of MMP-13 protein and to determine its prognostic value in breast cancer, and to define its relation to the clinicopathological features. Immunohistochemis...

Breast cancer (BC) impacts 2.3 million women each year, making it the most frequent diagnosed among female population. An unexpected link has been discovered between BC and alterations in mammary gut microbiota, suggesting their possible role development, prevention management. Studies suggest a distinct microbiome healthy breast tissue compared to tissue. The found be mostly enriched with bact...