I n probably the best-known finding from the Women’s Health Initiative, postmenopausal hormone therapy with estrogen and progestin was linked to a substantial increase in breast cancer risk. Now researchers think that the increase may be explained by an associated rise in breast density. Among women taking hormone therapy in the large, prospective women’s health study, both the density found on...

BACKGROUND Differences in ability to metabolize daidzein to equol might help explain inconsistent findings about isoflavones and breast cancer. We examined equol-producing status in relation to breast density, a marker of breast cancer risk, and evaluated whether an association of isoflavone intake with breast density differs by equol-producing status in a sample of Chinese immigrant women. M...

Physical inactivity and high mammographic breast density have both been associated with increased breast cancer risk. However, the association between physical activity and mammographic breast density remains inconsistent. In the European Prospective Investigation of Cancer (EPIC)-Norfolk population-based cohort study (United Kingdom), the authors investigated the cross-sectional association be...

BACKGROUND Clinicians determine degree of mammographic density based on tissue firmness on breast examination. The study aimed to compare breast density in mammography and clinical breast examination. MATERIALS AND METHODS Six-hundred sixty three women 40 years of age or older were studied. The breast exam density was graded from 1 to 4 by two expert surgeons and the mammographic parenchymal ...

Breast cancer is the most common cancer in women and the number of incidences keeps rising. Mammographic breast density has been recognized as a very important breast cancer risk and can also mask abnormalities. Information regarding mammographic breast density may be used for planning individualized breast cancer screening and treatment. Thus, breast density is increasingly assessed as the lim...

Breast cancer is one of the leading causes of fatality in women. Mammogram is the effectual modality for early detection of breast cancer. Increased mammographic breast density is a moderate independent risk factor for breast cancer, Radiologists have estimated breast density using four broad categories (BI-RADS) swearing on visual assessment of mammograms. The aim of this paper is to review ap...

Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development of breast tissue and possibly in the etiology of breast cancer. Breast density is one of the strongest predictors of breast cancer. In a cross-sectional analysis within the Nurses' Health Study, we compared the associations of plasma levels of endogenous IGF-I and IG...