Cytochromes P450 (P450) 2B6 and 3A5 are inactivated by bergamottin (BG). P450 2B6 metabolized BG primarily to M3 and M4 and one minor metabolite (M1). The metabolites were analyzed, and the data indicated that M1 was bergaptol, M3 was 5'-OH-BG, and M4 was a mixture of 6'- and 7'-OH-BG. Because 6'- and 7'-OH-BG were the primary metabolites, it suggested that P450 2B6 preferentially oxidized the ...

Porous ceramic microspheres are a desirable substance for bone tissue reconstruction and delivery applications. This study focuses on Mg–Ca silicate encapsulated in biodegradable poly (lactic-co-glycolic acid) (PLGA) to serve as biocompatible carrier the controlled release of vancomycin hydrochloride. In this regard, diopside (MgCaSi 2 O 6 ), bredigite (MgCa 7 Si 4 16 akermanite ) powders were ...

In the early nineteen eighties, Gunnar Carlsson proved the Segal conjecture on the stable cohomotopy of the classifying space BG of a finite group G. This led to an algebraic description of the ring of stable self-maps of BG as a suitable completion of the “double Burnside ring”. The problem of understanding the primitive idempotent decompositions of the identity in this ring is equivalent to u...

Research investigating interactions between aboveground (AG) and below-ground (BG) herbivores has been central to characterizing AG-BG linkages in terrestrial ecosystems, with many of these interactions forming the basis of complex food webs spanning the two subsystems. Despite the growing literature on the effects of AG and BG herbivores on each other, underlying patterns have been difficult t...

The rat beige (bg) autosomal recessive gene, causing Chediak-Higashi Syndrome (CHS) in rat, was mapped on Chr 17 by using synteny of rat to mouse and humans. The linkage between the beige gene and PCR-amplified microsatellite markers in (DA-bg x BN)F1 x DA-bg backcross progeny was analysed. The recombination frequency was 9.5% between Prl and Acrm and 19.1% between Acrm and bg. The proposed ord...

Evidence for the production in viva from pyridoxine of compounds with increased activity for certain lactic acid bacteria (1) and for the production of similar compounds by amination or oxidation procedures in vitro (2, 3) has been reported. Only a limited number of structures for the compounds resulting from amination or oxidation appeared possible; synthesis (4, 5) of certain of these resulte...