REASONS FOR PERFORMING STUDY Studies investigating the clinical efficacy of albuterol administered with the same propellant and commercially available delivery devices in horses with recurrent airway obstruction (RAO) are not currently available. OBJECTIVES To determine the efficacy of aerosolised albuterol administered to horses with RAO by means of 2 commercially available, hand-held delive...

Airway relaxation in response to isoprenaline, sodium nitroprusside (SNP) and electrical field stimulation (EFS) was compared under static and dynamic conditions. The capacity of relaxants to reduce airway stiffness and, thus, potentially contribute to bronchodilation was also investigated. Relaxation responses were recorded in fluid filled bronchial segments from pigs under static conditions a...

BACKGROUND The endurance shuttle walking test (ESWT) has shown good responsiveness to interventions in patients with chronic obstructive pulmonary disease (COPD). However, the minimal important difference (MID) for this test remains unknown, therefore limiting its interpretability. METHODS Patients with COPD who completed two or more ESWTs following pulmonary rehabilitation (n=132; forced exp...

Long-acting bronchodilators have been shown to improve multiple clinical outcomes in chronic obstructive pulmonary disease (COPD) including lung function, symptoms, dyspnea, quality of life, and exacerbations. Indacaterol is a novel, inhaled, long-acting β2-agonist providing 24-hour bronchodilation with once-daily dosing. It is currently approved for the maintenance treatment of COPD to be admi...

The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics. 121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and/...

TO THE EDITOR: The role of Toll-like receptor-7s (TLR7) in innate immunity against single-stranded RNA viruses is well established. Recently, our group found TLR7 agonists also relax guinea pig and human airway smooth muscle strips via production of nitric oxide (1, 2). Immunostaining identified extensive TLR7 expression on airway nerves, but none on smooth muscle; thus we hypothesized airway n...

The bronchodilating action of theophylline in COPD has been examined, with emphasis on its combined use with inhaled beta 2 agonists. The suggestion is made that failure to recognize the nonlinearity of the dose-response curves for bronchodilators has resulted in underestimating their combined action. Recent studies suggest that systemic theophylline has somewhat different actions on the airway...

Assessment of the bronchodilation response to short-acting beta2-adrenoreceptor agonists on pharmacologically induced bronchoconstriction has often been used to investigate airway smooth muscle beta2-adrenoreceptor function. However, little is known about factors affecting this response. In the present study, the bronchodilation response to 0.2 mg of salbutamol on histamine-induced bronchoconst...

In 20 patients with chronic bronchitis and moderate or severe airways obstruction inhalation of 40 mug of a new anticholinergic drug, Sch 1000, was found to produce stronger and more persistent bronchodilation than inhalation of 200 mug of salbutamol.