BACKGROUND Young children with sickle cell disease (SCD) are at risk for cognitive delay. In addition to biologic risk factors associated with SCD, environmental factors contribute to cognitive dysfunction within this cohort. METHODS We completed a single-arm, prospective cohort study. Children with SCD between the ages of 3 and 36 months and their caregivers were followed between October 201...

Few studies have addressed co-occurring methylmercury (MeHg) from maternal origin and ethylmercury (EtHg) from Thimerosal-containing vaccines (TCVs) during infant's neurodevelopment. We studied children (n=1139) from the Western Amazon based on combined (low, intermediate, and high) exposure to chronic MeHg from fish consumption and acute TCV- EtHg. Neurodevelopment outcomes were age of walking...

OBJECTIVE To examine the utility of the Bayley Infant Neurodevelopmental Screener (BINS) as a screening technique for premature, low birth weight infants. METHODS One hundred thirty-three preterm infants <1,500 grams received a BINS assessment at mean adjusted age 6.8 months and a Bayley Scales of Infant Development, Second Edition (BSID-II) assessment at mean adjusted age 12.9 months. Infant...

This issue of Pediatrics contains a meta-analysis by Qawasmi et al1 that is an evaluation of the effects of long-chain polyunsaturated fatty acid (LCPUFA) supplementation of infant formula on what is claimed to be measures of “infant cognition.” The analysis is based on performance of different dietary groups on the Bayley Scales of Infant Development (BSID) at ages up to 18 months. The authors...

BACKGROUND The relative role of socioeconomic status (SES), home environment and maternal intelligence, as factors affecting child cognitive development in early childhood is still unclear. The aim of this study is to analyze the association of SES, home environment and maternal IQ with child neurodevelopment at 18 months. METHODS The data were collected prospectively in the PHIME study, a ne...

CONTEXT Infants who are very preterm (born < or = 32 weeks of gestation) and very low birth weight (VLBW) (weighing < or = 1500 g) are at risk for poor developmental outcomes. There is increasing evidence that very preterm birth and VLBW have a considerable effect on motor development, although findings are inconsistent. OBJECTIVE To investigate the relationship between very preterm birth and...

Infants who have been hospitalized in a neonatal intensive care unit (NICU) may present with a multitude of challenges that put them at risk for delayed development. Early Intervention and specialized NICU follow up clinics are in place to help identify NICU graduates’ need for therapy services. Well-established, standardized assessments, such as the Bayley Scales of Infant and Toddler Developm...

Iron is a critical nutrient for brain development. Extremely low birth weight infants are at high risk because they deprived of iron transfer late in pregnancy. The Committee on Nutrition the American Academy Pediatrics recommends an intake least 2 mg/kg/day all preterm through 12 months age. deficiency that population exacerbated by rapid postnatal growth and blood loss phlebotomies. These def...

OBJECTIVE We assessed the neurodevelopment of infants with and without deformational plagiocephaly (DP), at an average age of 6 months. METHODS The Bayley Scales of Infant Development III (BSID-III) were administered to 235 case subjects and 237 demographically similar, control participants. Three-dimensional head photographs were randomized and rated for severity of deformation by 2 craniofa...