Over the last 10–15 years, there has been a pervasive trend toward initiation of chronic dialysis at higher levels of estimated GFR (eGFR) across a range of different patient groups and practice settings (1–5). This finding seems to suggest that on average patients are now initiating chronic dialysis substantially earlier in the course of their kidney disease than in previous years (3). In ligh...

Chronic fatigue syndrome (CFS), also known as chronic fatigue and immune dysfunction syndrome (CFIDS), myalgic encephalomyelitis, and so forth, has an unknown etiology and a poorly understood pathophysiology. Almost nothing is known of the cellular bioenergetics of CFS patients. The syndrome is a subject of increasing interest, though it is not a new phenomenon; medical literature going back ov...

The reaction between 2-chlorobenzylamine or 2-chlorobenzylalcohol and Pd(I(t)Bu)(2) (I(t)Bu = 1,3-di-tert-butylimidazol-2-ylidene) in benzene affords the dimeric complexes [Pd(I(t)Bu)(mu-NH{2-CH(2)C(6)H(4)})](2) and [Pd(I(t)Bu)(mu-O{2-CH(2)C(6)H(4)})](2); the latter has been structurally characterised. The syntheses, structural characterisation and reactivity of the Pd-NHC amine complexes [(I(t...

The possibility of altered B-adrenergic receptors and/or adenyl cyclase activity in fibroblasts from patients with cystic fibrosis (CF) has been raised by several groups of investigators. Buchwald (1) reported a greater increase in CAMP’ after isoproterenol stimulation in CF than in normal fibroblasts and this was confirmed by Roscher et al. (2) for CF and normal fibroblasts in fresh medium. Fu...

A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides a...

Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon-carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview ...

Two divergent synthetic routes are reported offering access to four quinolone natural products from Pseudonocardia sp. CL38489. Key steps to the natural products involved a regioselective epoxidation, an intramolecular Buchwald-Hartwig amination and a final acid-catalysed 1,3-allylic-alcohol rearrangement to give two of the natural products in one step. This study completes the synthesis of all...

Håkansson K, MD, Konge L, MD, phD, Thomsen SF, MD, phD, Backer V, MD, DmSci, von Buchwald C, MD, DmSci 1) Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark 2) Centre for Clinical Education, University of Copenhagen and Capital Region of Denmark, Copenhagen, Denmark 3) Department ...