Metastasis depends upon cancer cell growth and survival within the metastatic niche. Tumors which remodel their glycocalyces, by overexpressing bulky glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in oncogenesis remains poorly understood. Here we report that a bulky glycocalyx promotes the expansion of disseminated tumor cells in vivo by foster...

PURPOSE To evaluate conventional brachytherapy (BT) plans using dose-volume parameters and high resolution (3 Tesla) MRI datasets, and to quantify dosimetric benefits and limitations when MRI-guided, conformal BT (MRIG-CBT) plans are generated. MATERIAL AND METHODS Fifty-five clinical high-dose-rate BT plans from 14 cervical cancer patients were retrospectively studied. All conventional plans...

MR Spectroscopy (MRS) has great potential for guiding radiotherapy of prostate cancer by identifying bulky and/or high grade tumors suitable for dose escalation (1,2). However, image guided therapy typically employs permanently implanted gold seed fiducial markers (GSFM), which aid in daily prostate localization prior to treatment. The impact of these gold seed markers on the quality of MRS is ...

Sebaceous adenocarcinoma is a rare adnexal tumor that can affect the skin and is divided into ocular, a more common form and extra ocular, of a rarer occurrence. We report the case of a patient diagnosed with Acquired Immune Deficiency Syndrome (AIDS) who developed an extra ocular, bulky and fast-growing sebaceous adenocarcinoma on the face. The literature has suggested that transplanted patien...

Early stage testicular germ cell tumors are highly curable malignancies, but the need for close radiologic and biomarker surveillance is pivotal. Even in the setting of recurrence, rescue therapy has been successfully implemented. The present report describes a patient that had rapid and aggressive recurrence after radical orchiectomy for a testicular germ cell tumor and presented with bulky di...

Malignant perivascular epithelioid cell tumor (PEComa) is a rare tumor composed of hybrid tumor cells characterized by immunoreactivity for both melanocytic and smooth muscle markers. This paper describes the uncommon esophageal location of an 8 cm PEComa in a 75-year-old Caucasian man who was presented with ingravescent dysphagia. Although PEComas arising within the gastrointestinal tract are ...

asymptomatic and there is a delay in diagnosis most of the time. During management of invasive hydatiform mole, ureteral obstruction should be kept in mind. In the case of large, bulky tumors extending into the parametrium, the possibility of ureteral compression should be kept in mind and excluded by appropriate imaging techniques to prevent loss of renal function due to a complication of a cu...

Facing supply uncertainty of bulky wastes, the capacitated multi-product stochastic network design model for bulky waste recycling is proposed in this paper. The objective of this model is to minimize the first-stage total fixed costs and the expected value of the second-stage variable costs. The possibility of operation costs and transportation costs for bulky waste recycling is considered ...

Thirty patients had right trisegmentectomy for 19 primary hepatic malignant tumors, seven localized liver metastases and four benign lesions. A technical refinement that aided resection of bulky posterior and superior tumors was intrahepatic identification and control of the right hepatic vein. The operative mortality was 3.3 per cent. Late hepatic insufficiency was not observed. More than one-...

BACKGROUND AND PURPOSE Solitary extramedullary plasmacytoma (SEP) is rare. The purpose of this study was to determine the CT and MR imaging features of SEP of the nasal tract. METHODS We retrospectively reviewed three CT and two MR images of three histologically proved cases in two men and one woman aged 43-66 years. RESULTS The plasmacytomas predominantly involved the nasopharynx in two ca...