conclusions all plants could inhibit mushroom tyrosinase, but more investigations on human tyrosinase and clinical studies are needed. results the hydroalcoholic extract of p. alkekengi showed the most tyrosinase inhibitory effect with ic50 of 0.09 mg/ml vs. 0.38, 0.38 and 2.82 mg/ml of b. persicum, a. rosea and m. vulgare, respectively. m. vulgare exhibited uncompetitive inhibition and other p...

background & aim: medicinal plants are most valuable and useful sources as productive factors of drugs. production and extraction of secondary metabolites have a huge economical importance in recent years. carvone is a compound in bunium persicum fruit and shoot and, it is one of the wide range varieties of valuable and useful secondary metabolites. due to limited crop production, using app...

objective: nowadays notable increase in acquired resistance of candida species to antifungal drugs and necessity of using agents with antifungal properties is unavoidable. in some plants due to presence of components such as polyphenols have antimicrobial properties. in this study antifungal effects of essential oils of thymus vulgaris, petroselinum crispum, cuminum cyminum and bunium persicum ...

AIM Developing antitumor drugs from natural products is receiving increasing interest worldwide due to limitations and side effects of therapy strategies for the second leading cause of disease related mortality, cancer. METHODS The antiproliferative activity of a methanolic extract from the aerial parts of Marrubium persicum extract was assessed with the MCF-7 breast cancer cell line using t...

Background & Aims: Bunium persicum Boiss. Belongs to Apiaceae family and its fruit contains high level of essential oils used as native medicinal plant in traditional medicine. Methods: The essential oil of Bunium persicum (EOBP) was extracted by Clevenger apparatus using hydrodistillation. Lethal dose, 50% (LD50) was calculated based on Lorke’s method. Effects of EOBP (20- 80 mg/kg) on upper g...

The present study evaluated the potential benefit of supplementation with Heracleumpersicum as an adjunctive therapy to atorvastatin in dyslipidemic subjects. In a randomized, open-label, clinical trial, 100 dyslipidemic subjects were randomly assigned to: (1) H. persicum group (n=50, completers=18), receiving H. persicum extract (500 mg/day) + atorvastatin (10 mg/day) for 8 weeks, or (2) atorv...