There are documented clinical drug-drug interactions between bupropion and the CYP2D6-metabolized drug desipramine resulting in marked (5-fold) increases in desipramine exposure. This finding was unexpected as CYP2D6 does not play a significant role in bupropion clearance, and bupropion and its major active metabolite, hydroxybupropion, are not strong CYP2D6 inhibitors in vitro. The aims of thi...

Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid. Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to its antidepressant activity, this metabolite may also contribute to the smoking-cessation properties of bupropion. This study investigated the effects of hydrobupropion enantiomers on monoamine transporters and nicot...

we present a case report of bupropion-induced diplopia in a 26-year-old woman who suffered from atypical depression. âfter four weeks of taking bupropion (225 mg per day) she complained of headaches, blurred vision, and diplopia. no neurological and ophthalmologic abnormal signs were found. her brain magnetic resonance imaging (mrï) and magnetic resonance venography (mrv) were normal as well. â...

Bupropion is used clinically to treat depression and to promote smoking cessation. It is metabolized by CYP2B6 to its activemetabolite hydroxybupropion, yet alterations in CYP2B6 activity have little impact on bupropion plasma levels. Furthermore, less than 10%of a bupropion dose is excreted as urinary bupropion and its characterized metabolites hydroxybupropion, threohydrobupropion, and erythr...

murraya koenigii l. (rutaceae), commonly known as curry leaf tree, closely associated with south india where the word “curry” originates from the tamil “kari” for spiced sauces. curry leaves are a rich source of carbazole alkaloids which possess various biological activities such as antitumor, antioxidant and anti-inflammatory. curry leaf has a potential role in the treatment of diabetes. reser...

Nicotine addiction is a chronic relapsing condition that can be difficult to treat. Until recently, pharmacological options for the treatment of tobacco dependence were primarily limited to nicotine replacement therapy (NRT). Sustained-release bupropion (bupropion SR) is the first non-nicotine pharmacological treatment approved for smoking cessation. Bupropion SR is recommended for first-line p...

N-methylbupropion was selected as a potential prodrug from our in vitro screening of analogues of bupropion described in the preceding paper. This study describes in vivo pharmacokinetics of N-methylbupropion in the guinea-pig animal model, which is reported to best predict human metabolism of bupropion. The suitability of the guinea pig was established by studying N-demethylation of N-methylbu...

BACKGROUND Bupropion hydrochloride is recommended for smoking cessation; however, there have been relatively few clinical trials examining its efficacy. METHODS A total of 244 current smokers were enrolled in an outpatient randomized blinded smoking cessation trial conducted at the San Francisco Veterans Affairs Medical Center, San Francisco, Calif. Of the 244 participants, 121 received a 7-w...

Bupropion is an atypical antidepressant that also has utility as a smoking cessation aid. Hydroxybupropions are major metabolites of bupropion and are believed to contribute to antidepressant and perhaps smoking cessation activities. Because bupropion metabolism is more similar in humans and mice than in humans and rats, the present study investigated effects of hydroxybupropion enantiomers in ...

Neuroleptics are widely prescribed drugs for the treatment of schizophrenia and related psychiatric disorders. Tardive dyskinesia (TD) is a late complication of prolonged neuroleptic treatment. Despite much research, the pathogenesis of TD remains elusive. It may be caused by loss of dopaminergic cells, due to free radicals as a product of high synaptic dopamine levels. Tardive dyskinesia has b...