Analogs of gonadoliberin (GnRH) are widely used in cattle to synchronize estrus and to induce ovulation, as well as for the treatment of ovarian cysts. The aim of this study was to compare the plasma profiles of LH and progesterone and the follicular dynamics in response to the administration of gonadorelin, lecirelin, or buserelin at the dose recommended to induce ovulation. In addition, the b...

F. Hadziselimovic, MD, University Children’s Hospital Basel, Römergasse 8, CH-4005 Basel (Switzerland) Cryptorchidism is a disorder of the hypothalamic-pituitary-gonadal axis and is not a malformation. We advocate early treatment (10 months of age) to avoid pronounced secondary gonadal changes starting after 12 months of age. The lower the testes are situated the better their histology; the you...

The mucosa of the nasal cavity has relatively high premeability for peptides. Because of the digestive peptidase activity of the gut, the nasal pathway is currently the route of choice for nonparenteral administration of many peptides including gonadotropin releasing hormone analogues (GnRH-a) . Nevertheless, the transmucosal route of administration may have some problems. Variations exist from...

The hereditary disorder acute intermittent porphyria is potentially fatal. Many more females present with active disease than males and some have attacks related to their menstrual cycle and pregnancy. We present a female patient who was diagnosed while pregnant at 19 years. She subsequently developed life-threatening attacks pre-menstrually at 24 years; these were associated with weight loss. ...

pituitary suppression by depot gnrh agonist may be excessive for ovarian stimulation. this study compares the efficacy of a single half-dose depot triptorelin and reduced-dose daily buserelin in a long protocol icsi/et. methods: a total of 182 patients were randomized into two groups using sealed envelopes. pituitary desensitization was obtained in group 1 (91 patients) with half-dose (1.87 mg)...

BACKGROUND AND AIM Suboestrus constitutes the largest factor responsible for poor reproductive efficiency in buffaloes. Therefore, oestrus synchronization (OS) and fixed-time artificial insemination (AI) is considered an alternative approach to enhance reproductive efficiency in buffaloes. Thus, the present study was carried out to study the efficacy of modified Ovsynch protocol with fixed time...

overall, 531 dairy cows were inseminated with the aim to study their reproductive performance following administration of gnrh analogue on different days of estrous cycle with different doses. these cows were divided into six treatment and one control group. depending upon different treatment groups, buserelin acetate was injected at a dose of 10.5 µg or 21.0 µg on different days (0, 5 or 12) o...

The therapeutic options for the treatment of androgea-independent prostatic cancers are rather limited; this Is mainly because our under standing of the local mechanisms involved In the control of androgen independent proliferation of the tumor is stlH very poor. The present experlmeats have been performed to verify whether luteinizing hormone releasing hormone (LHRH) agonists may possess a dir...

Gonadotropin-releasing hormone (GnRH) stimulates release of pituitary gonadotropins by activating specific plasma membrane receptors. In the present studies, we have used activators of the Ca2+- and phospholipid-dependent protein kinase (protein kinase C) to probe the binding characteristics of agonist- or antagonist-occupied GnRH receptors in intact cell cultures, using a radioligand receptor ...

Sheep pituitary cells prelabelled with radioactive [35S] sulfate (35SO4(2-)) were incubated with different concentrations of LH-RH and the release of LH (lutropin) into the medium was monitored in terms of immunoprecipitable [35S] sulfated LH radioactivity and estimation of LH in the same sample by radioimmunoassay. A dose dependent response was obtained with a maximum of a 16 fold increase in ...