High levels of HDL-cholesterol (HDL-C) protect against coronary heart disease susceptibility, but the metabolic mechanisms underlying elevated HDL-C levels are poorly understood. We now report the turnover of isologous radioiodinated HDL apolipoproteins, apo A-I and apo A-II, in 15 female subjects on a metabolic diet with HDL-C levels ranging from 51 to 122 mg/dl. The metabolic parameters, frac...

Previous studies showed that transgenic mice overexpressing either apolipoprotein AI (apoAI) or apolipoprotein AII (apoAII), the major proteins of HDL, exhibited elevated levels of HDL cholesterol, but, whereas the apoAI-transgenic mice were protected against atherosclerosis, the apoAII-transgenic mice had increased lesion development. We now examine the basis for this striking functional heter...

La variabilité intra-individuelle du cholestérol, et plus précisément LDL-cholestérol, mais, possiblement aussi, celle HDL-cholestérol apparaissent comme potentiellement délétères. Plusieurs études ont objectivé une association indépendante entre la d’une part, le risque d’accidents cardiovasculaires (infarctus myocarde, accident vasculaire cérébral) mortalité globale, d’autre part. Par ailleur...

High density lipoprotein (HDL) cholesterol levels and cholesterol efflux capacity (CEC) are inversely correlated with coronary artery disease (CAD) risk. Myeloperoxidase (MPO) derived oxidants and HDL proteome changes are implicated in HDL dysfunction in subjects with CAD in the United States; however, the effect of MPO on HDL function and HDL proteome in ethnic Chinese population is unknown. W...

In the Twin Cities Prospective Study, executive men aged 45 to 55 and "healthy" at the entry examinations in 1948 were re-examined yearly to 1975. Follow-up through 1983 lost only one man. High density lipoprotein cholesterol (HDL) in the serum was measured in 1955 with a method checked with recent standard methods. Among 217 men, 130 were dead by 1983, 56 from coronary heart disease (CHD) and ...

OBJECTIVE The purpose of this study was to analyze the consequences of HDL oxidation for paraoxonase-1 metabolism and function. METHODS AND RESULTS HDL was oxidized with AAPH, copper ions, and hypochlorite. Secretion studies were performed using human paraoxonase-1-transfected cells lines and primary rat hepatocytes. Stability studies were performed with recombinant paraoxonase. Conditioned m...

A low level of high-density lipoprotein (HDL) cholesterol is characteristic of insulin resistance and hypertriglyceridemia and likely contributes to the increased risk of cardiovascular disease associated with these conditions. One pathway involves enhanced clearance of lipolytically modified HDL particles, but the underlying mechanisms remain poorly understood. Here, we examine the effect of t...

A low level of high-density lipoprotein (HDL) cholesterol is characteristic of insulin resistance and hypertriglyceridemia and likely contributes to the increased risk of cardiovascular disease associated with these conditions. One pathway involves enhanced clearance of lipolytically modified HDL particles, but the underlying mechanisms remain poorly understood. Here, we examine the effect of t...

Zewinger et al. studied 3310 patients undergoing coronary angiography in the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study and determined that serum amyloid A (SAA) concentrations predicted all-cause and cardiovascular mortality. Patients with low SAA levels and higher high-density lipoprotein (HDL) cholesterol levels had lower all-cause and cardiovascular mortality. In contrast, pa...