Seizures are the result of a sudden and temporary synchronization of neuronal activity, the reason for which is not clearly understood. Astrocytes participate in the control of neurotransmitter storage and neurotransmission efficacy. They provide fuel to neurons, which need a high level of energy to sustain normal and pathological neuronal activities, such as during epilepsy. Various genetic or...

Mice treated with buthionine sulfoximine, an inhibitor of glutathione synthesis, showed striking alterations of morphology of lung type 2 cell lamellar bodies (swelling and disintegration) and mitochondria (degeneration) and of lung capillary endothelial cells (mitochondrial swelling). These effects probably may be ascribed to glutathione deficiency; administration of glutathione monoester prot...

A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields of the desired cyclophanes. Thus, arylene-ethynylene moieties with terminal sulfoximine or formyl functions are linked to binaphthyl cores and the...

Lethal and sub-lethal effects of a novel sulfoximine insecticide, sulfoxaflor, against Asian citrus psyllid and its primary parasitoid under laboratory and field conditions Gurpreet S. Brar, Xavier Martini & Lukasz L. Stelinski To cite this article: Gurpreet S. Brar, Xavier Martini & Lukasz L. Stelinski (2017) Lethal and sublethal effects of a novel sulfoximine insecticide, sulfoxaflor, against...

Cell suspension cultures of tomato, Lycopersicon esculentum Mill. cv VFNT-Cherry, produce phytochelatins (poly[gamma-glutamylcysteinyl]glycines) when exposed to cadmium. The synthesis of these peptides is accompanied by a decline in cellular levels of glutathione. Buthionine sulfoximine, an inhibitor of glutathione synthesis, inhibits the sustained production of phytochelatins. However, phytoch...

The inhibitory influence of the toxin on the growth of Chlorella was completely reversible in the presence of l-methionine. A similar reversal has not yet been accomplished in tobacco. That the mechanism of action is similar in both organisms, however, is suggested by the fact that methionine sulfoximine, a known methionine antagonist, produced chlorotic lesions in tobacco leaves that were indi...

In this study the role of glutathione (GSH) in sulfur mustard -induced oxidative stress and cytotoxicity, in human skin fibroblast cell line (HF2FF) was evaluated. Sulfur mustard-induced superoxide radical and hydrogen peroxide formation were evaluated by determination of superoxide dismutase and catalase activity in cell lysate. The cytotoxicity of sulfur mustard was estimated by lactate dehyd...