Growth hormone (GH) structure is stabilised by two disulphide bonds, C53-C165 and C182-C189 in human GH. Researchers have investigatedthe role of these structural features since the late 1960s. Early studies implied that the disulphide bonds would not be importantfor biological activity of GH. However, more advanced techniques, as well as clues from patients carrying mutations in their GH1 gene...

This paper develops a Bayesian quantile regression model with time-varying parameters (TVPs) for forecasting inflation risks. The proposed parametric methodology bridges the empirically established benefits of TVP regressions ability to flexibly whole distribution inflation. In order make our approach accessible and relevant forecasting, we derive an efficient Gibbs sampler by transforming stat...

For an r-uniform hypergraph H and a family of hypergraphs F, the relative Turán number ex(H,F) is maximum edges in F-free subgraph H. In this paper we give lower bounds on for certain families cycles F such as Berge loose cycles. particular, if Cℓ3 denotes set all 3-uniform ℓ-cycles with degree Δ, proveex(H,C43)≥Δ−3/4−o(1)e(H),ex(H,C53)≥Δ−3/4−o(1)e(H), these are tight up to o(1) term.

Time trends of age-standardized rate (ASR) of uterine cancer incidence (ICD-10: cervix uteri (C53), corpus uteri (C54)) were compared among 18 selected cancer registries and ethnic/racial groups in East Asia, Europe and the USA. The data source was the World population was used for age-standardization. Figure 1 shows the time trends of ASR of cervix uteri cancer incidence. In East Asia, Hong Ko...

Homeostasis of the endoplasmic reticulum (ER) is essential for normal cellular functions. Disturbance of this homeostasis causes ER stress and activates the Unfolded Protein Response (UPR). The Ufm1 conjugation system is a novel Ubiquitin-like (Ubl) system whose physiological target(s) and biological functions remain largely undefined. Genetic study has demonstrated that the Ufm1-activating enz...

The effects of both Salmonella typhimurium infection and 5 mM ofloxacin treatment on 2 mM glutamine and 5 mM glucose metabolism in the enterocyte-like Caco-2/TC-7 cell line were studied. These cells utilized glutamine (212.07 +/- 16.75 [mean +/- standard deviation] nmol per h per 10(6) viable cells) and, to a lesser extent, glucose (139.63 +/- 11.52 nmol per h per 10(6) viable cells). Metabolis...

Analyzing International Monetary Fund (IMF) data, we find that overly optimistic growth expectations for a country induce economic contractions few years later. To isolate the causal effect, take an instrumental variable approach—exploiting randomness in allocation of IMF mission chiefs. We first document chiefs differ their individual degrees forecast optimism, yielding quasi-experimental vari...

With the development of computer technologies and invention internet, many concepts have entered our lives. starting wide usage globalized internet network, concept machine learning has emerged in time for smarter management data flow big dimensions. In line with technological developments, all activities began to be carried digital environment as a result this, e-commerce E-commerce is one are...

this article is a comparative study of estimation power of artificial neural networks and autoregressive time series models in inflation forecasting. using 37 years iran’s inflation data, neural networks performs better on average for short horizons than autoregressive models. this study shows usefulness of early stopping technique in learning stage of neural networks for estimating time series...

We propose serial correlation robust asymptotic confidence bands for the receiver operating characteristic (ROC) curves estimated by quasi-maximum likelihood in the binormal model. Our simulation experiments confirm that this new method performs fairly well in finite samples. The conventional procedure is found to be markedly undersized in terms of yielding empirical coverage probabilities lowe...