نتایج جستجو برای: ca2 sensitization

تعداد نتایج: 67416  

Journal: :British journal of pharmacology 2006
Dedmer Schaafsma Mark Boterman Anne-Margreet de Jong Iris Hovens Jelte-Maarten Penninks S Adriaan Nelemans Herman Meurs Johan Zaagsma

In airway smooth muscle (ASM), full and partial muscarinic receptor agonists have been described to have large differences in their ability to induce signal transduction, including Ca2+-mobilization. Despite these differences, partial agonists are capable of inducing a submaximal to maximal ASM contraction. To further elucidate transductional differences between full and partial muscarinic rece...

2012
Suzanne Doolen Camille B Blake Bret N Smith Bradley K Taylor

BACKGROUND Central sensitization in the spinal cord requires glutamate receptor activation and intracellular Ca2+ mobilization. We used Fura-2 AM bulk loading of mouse slices together with wide-field Ca2+ imaging to measure glutamate-evoked increases in extracellular Ca2+ to test the hypotheses that: 1. Exogenous application of glutamate causes Ca2+ mobilization in a preponderance of dorsal hor...

2008
Greg A. Knock Yasin Shaifta Vladimir A. Snetkov Benjamin Vowles Svetlana Drndarski Jeremy P.T. Ward Philip I. Aaronson

AIMS We investigated the role of src family kinases (srcFK) in agonist-mediated Ca2+-sensitization in pulmonary artery and whether this involves interaction with the rho/rho-kinase pathway. METHODS AND RESULTS Intra-pulmonary arteries (IPAs) and cultured pulmonary artery smooth muscle cells (PASMC) were obtained from rat. Expression of srcFK was determined at the mRNA and protein levels. Ca2+...

Journal: :Circulation research 2002
Avril V Somlyo

Gprotein–coupled receptors (GPCRs) activated by a wide variety of agonists can switch on myosin light chain phosphorylation and force in smooth muscle. The extent of myosin light chain phosphorylation reflects activity of both the Ca /calmodulin–dependent myosin light chain kinase (MLCK) and the myosin light chain phosphatase. Thus, at constant Ca and MLCK activity, processes that inhibit myosi...

Journal: :Journal of neurophysiology 1985
K J Gingrich J H Byrne

The defensive gill-withdrawal reflex in Aplysia has proven to be an attractive system for analyzing the neural mechanisms underlying simple forms of learning such as habituation, sensitization, and classic conditioning. Previous studies have shown that habituation is associated with synaptic depression and sensitization with presynaptic facilitation of transmitter release from sensory neurons m...

2005
Moo-Yeol Lee Young-Ho Lee Kyung-Min Lim Seung-Min Chung Ok-Nam Bae Heon Kim Choong-Ryeol Lee Jung-Duck Park Jin-Ho Chung

Chronic exposure to arsenic is well known as the cause of cardiovascular diseases such as hypertension. To investigate the effect of arsenic on blood vessels, we examined whether arsenic affected the contraction of aortic rings in an isolated organ bath system. Treatment with arsenite, a trivalent inorganic species, increased vasoconstriction induced by phenylephrine or serotonin in a concentra...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2008
Wensheng Chen Raouf A Khalil

Vascular resistance and blood pressure (BP) are reduced during late normal pregnancy (Norm-Preg). In contrast, studies in human preeclampsia and in animal models of hypertension in pregnancy (HTN-Preg) have suggested that localized reduction in uterine perfusion pressure (RUPP) in late pregnancy is associated with increased systemic vascular resistance and BP; however, the vascular mechanisms i...

Journal: :The Journal of General Physiology 1993
S Frings

Effects of neurotransmitters on cAMP-mediated signal transduction in frog olfactory receptor cells (ORCs) were studied using in situ spike recordings and radioimmunoassays. Carbachol, applied to the mucosal side of olfactory epithelium, amplified the electrical response of ORCs to cAMP-generating odorants, but did not affect unstimulated cells. A similar augmentation of odorant response was obs...

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