Severe or chronic disease can lead to cachexia which involves weight loss and muscle wasting. Cancer cachexia contributes significantly to disease morbidity and mortality. Multiple studies have shown that the metabolic changes that occur with cancer cachexia are unique compared to that of starvation. Specifically, cancer patients seem to lose a larger proportion of skeletal muscle mass. There a...

Cachexia has been known to physicians since ancient Greek times as a 'signum mali ominis' in various diseases indicating end stage disease and poor quality of life. Cardiac cachexia is recently receiving growing attention as modern treatment options prevent early death from cardiac events and more patients live with chronic compensated heart failure. Nevertheless, observation and clinical docum...

PURPOSE/OBJECTIVES To develop a tool to identify patients with cancer who suffer from cachexia throughout all stages of the disease. DESIGN Tool development study. SETTING Oncology day care, follow-up clinics, radiotherapy, and hospice home care. SAMPLE 90 patients with cancer (25 men and 65 women). METHODS The Cachexia Assessment Scale (CAS) was created based on a thorough review of th...

BACKGROUND Cachexia is a state of involuntary weight loss common to many chronic diseases. Experimental data, showing that cachexia is related to the enhancement of acute phase response reaction, led to the new definition of cachexia that included, aside from the principal criterion of weight loss, other "minor criteria", Amongst them are levels of C-reactive protein (CRP), albumin and hemoglob...

Cancer cachexia, the unintentional loss of lean body mass, is associated with decreased quality of life and poor patient survival. Hypogonadism, involving a reduction in circulating testosterone, is associated with the cachectic condition. At this time there is a very limited understanding of the role of hypogonadism in cancer cachexia progression. This gap in our knowledge is related to a lack...

AIMS Adiponectin is a fat-derived hormone involved in the regulation of metabolism. Adiponectin concentration is inversely related to body weight and, in animals, causes weight loss. We, therefore, measured adiponectin concentration in patients with heart failure (HF) and cachexia. METHODS AND RESULTS Serum adiponectin concentrations were measured in three groups of patients with coronary art...

Cancer cachexia is a complex syndrome, characterized by weight loss consisting of skeletal muscle loss and adipose tissue wasting, leading to poor outcomes. There are no established treatments for cancer cachexia, although recent pre-clinical and clinical studies have shown the promising effects of several agents including ghrelin, myostatin/activin pathway antagonists, androgenic steroids and ...

Rationale: Previous studies have shown that serum albumin data from an individual can indicate the onset of cancer cachexia, provide information about a patient's nutritional status, and also serve as biomarker for prognosis patients with cachexia. However, relationship between mortality in cachexia remains unclear.

BACKGROUND Cachexia is a multifactorial metabolic syndrome with high morbidity and mortality in patients with advanced cancer. The diagnosis of cancer cachexia depends on objective measures of clinical symptoms and a history of weight loss, which lag behind disease progression and have limited utility for the early diagnosis of cancer cachexia. In this study, we performed a nuclear magnetic res...

Physical exercise has important effects on secondary prevention or intervention against several diseases. Although there are good reasons to recommend regular physical activity in patient populations, recommending exercise is not a straightforward endeavor in patients with chronic diseases. Cachexia, a severe skeletal muscle wasting syndrome, is often associated with numerous chronic diseases, ...