نتایج جستجو برای: cadm

تعداد نتایج: 76  

2011
Zoe E Betteridge Harsha Gunawardena Neil J McHugh

Autoantibodies targeting intracellular proteins involved in key processes are detected in patients with idiopathic inflammatory myopathies. These myositis-specific autoantibodies have been increasingly demonstrated to correlate with distinct clinical phenotypes within the myositis spectrum. This review highlights the clinical associations of the myositis-specific autoantibodies, with particular...

Journal: :Lupus 2015
T Kurita S Yasuda O Amengual T Atsumi

Interstitial lung disease (ILD) in patients with polymyositis (PM) and dermatomyositis (DM) is often resistant to treatment and life threatening, being recognized as one of the severest complication in these autoimmune disorders. Patients with clinically amyopathic dermatomyositis (CADM) or those with anti-CADM140/MDA5 antibody are especially prone to develop rapidly progressive interstitial pn...

2010
Ran Nakashima Tsuneyo Mimori

Autoantibodies to various cellular constituents are detected in the sera of patients with idiopathic inflammatory myopathy (IIM). These autoantibodies are closely associated with characteristic clinical manifestations of the diseases. Therefore, autoantibodies give us much information in clinical diagnosis, classification, prediction of prognosis and choice of treatment in patients with IIM. Du...

2016
Jin-Min Peng Bin Du Qian Wang Li Weng Xiao-Yun Hu Chan-Yuan Wu Yan Shi

INTRODUCTION Patients with idiopathic inflammatory myopathies (IIMs) are sometimes complicated with life-threatening conditions requiring intensive care unit (ICU) admission. In the past, owing to the low incidence of IIM, little was known about such patients. Our aim was to investigate the clinical features and outcomes of these patients and identify their risk factors for mortality. METHODS...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Neev Golan Elena Kartvelishvily Ivo Spiegel Daniela Salomon Helena Sabanay Katya Rechav Anya Vainshtein Shahar Frechter Galia Maik-Rachline Yael Eshed-Eisenbach Takashi Momoi Elior Peles

The interaction between myelinating Schwann cells and the axons they ensheath is mediated by cell adhesion molecules of the Cadm/Necl/SynCAM family. This family consists of four members: Cadm4/Necl4 and Cadm1/Necl2 are found in both glia and axons, whereas Cadm2/Necl3 and Cadm3/Necl1 are expressed by sensory and motor neurons. By generating mice lacking each of the Cadm genes, we now demonstrat...

Journal: :Internal medicine 2012
Yoshikata Morita Shogo Kuwagata Noriko Kato Yoshinori Tsujimura Hiromi Mizutani Mitsuhiro Suehiro Motohide Isono

Interstitial lung disease (ILD) frequently accompanies polymyositis (PM) and dermatomyositis (DM) and is a major cause of mortality. The rapid diagnosis of ILD is paramount. However, the early changes of presymptomatic ILD are difficult to detect. We present a patient with DM who had positive uptake in the lung of FDG-PET/CT as well as 'mechanic's hands' appearance, increased serum ferritin and...

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