Cancer arises from mutations accruing within cancer cells, but the tumor microenvironment (TME) is believed to be a major, often neglected, factor involved in therapy resistance and disease progression. Cancer-associated fibroblasts (CAFs) are prominent key components of TME most types solid tumors. Extensive research over past decade revealed their ability modulate metastasis, angiogenesis, me...

Multi-Modal Targeting Strategy for Breast Cancer In article number 2000145 by Sreejith Raveendran, D. Sakthi Kumar and co-workers, a multi-modal targeting strategy breast cancer using combinatorial nanodrug complex is studied ultra-structural visualization of subcellular multiple parallel damage caused to cells are demonstrated serial-block-face scanning electron microscopy. Mechanistic conform...

objective(s): berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. in this study, we examine...

Intra-tumor bacteria promote tumor growth and inactivate cancer-chemotherapeutics, causing poor treatment prognoses. Combined administration of cancer-chemotherapeutics antibiotics may disturb the oral intestinal microflora in critically-ill patients. To establish intra-tumor co-delivery antibiotics, gemcitabine ciprofloxacin are loaded so-called “self-targeting”, highly blood-compatible, synth...

Introduction: In this study, we explore in detail cell-specific targeting efficacy of nano-photo-thermal therapy (NPTT) method and the resulting responses that are induced by variable laser intensities and exposure times in cancer cells to induce selective apoptosis. We delineate the synthesis of a high-yielding synthetic F-AuNPs by tailoring the surface of gold nanoparticles ...

in this study, the folate decorated biodegradable poly (lactide-co-glycolide) (plga) nanoparticles were developed for tumor targeting of anticancer agents. due to the overexpression of the folate receptor on tumor surface, the folate has been efficiently employed as a targeting moiety for various anticancer agents to avoid their non-specific attacks on normal tissues and also to increase their ...