نتایج جستجو برای: canine lymphomas
تعداد نتایج: 51083 فیلتر نتایج به سال:
With the purpose of shedding light on some doubts in veterinary oncology, the present article intends to compare the results of histopathological and immunohistochemical examinations of unspecific round cell neoplasia, to realize immunophenotyping of canine lymphoma cases, to establish the T or B origin of neoplastic cells, and to determine the degree of proliferation and apoptosis of lymphomas...
BACKGROUND p53 plays a key role in the apoptotic event induced by chemotherapeutic agents. Mutation of p53 gene has been observed in various spontaneous tumors in humans and is associated with a poor prognosis. p53 abnormalities have been evaluated in several tumors in dogs; however, the association of p53 gene mutation with clinical outcome in dogs with lymphoma has not been documented. HYPO...
Monoclonal antibodies are leading agents for therapeutic treatment of human diseases, but are limited in use by the paucity of clinically relevant models for validation. Sporadic canine tumours mimic the features of some human equivalents. Developing canine immunotherapeutics can be an approach for modeling human disease responses. Rituximab is a pioneering agent used to treat human hematologic...
Lymphomas, cancers originating in components lymphopoietic, are very common in dogs. The most used diagnostic methods for canine lymphoma are histopathology and immunohistochemistry. Immunohistochemistry is a technique employing labeled antibodies able to identify antigens ̈in situ ̈, which score in this type of neoplasm and the degree of cell proliferation. The most commonly used markers for ca...
Canine systemic lupus erythematosus. Transmission of serologic abnormalities by cell-free filtrates.
The presence of viruses was sought in a colony of dogs bred from parents with systemic lupus crythematosus (SLE). Cell-free filtrates prepared from the spleens of these animals were injected into newborn dogs, mice, and rats. The canine recipients developed antinuclear antibody (ANA) and positive lupus erythematosus (LE) cell tests: ANA and, in some cases, antinative DNA antibodies were produce...
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