Vilsmeier Several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via Ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. The diversity of these quinolinyl Ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. Among them, compounds 2d, 2n, 2p, 4a, 4c and<strong...

A mixture of cysteamine and glyoxylate, proposed by Hamilton et al. to form the physiological substrate of hog kidney D-amino acid oxidase (Hamilton, G. A., Buckthal, D. J., Mortensen, R. M., and Zerby, K. W. (1979) Proc. Natl. Acad. Sci. U. S. A. 76, 2625-2629), was confirmed to act as a good substrate for the pure enzyme. As proposed by those workers, it was shown that the actual substrate is...

A total of 20 biogenic carboxylic acids, which contain one to three negatively charged -COOgroup(s), were investigated as dispersion additives in the processing of ceramic particles. Only carboxylic acids containing one or more hydroxyl groups were able to disperse ct-A120 3 particles in aqueous suspensions. Detailed studies of two carboxylic acids, citric acid and tricarballylic acid were unde...

A newsynthetic route has been developed for the total synthesis of ozenoxacin. In this avoided toxic heavy metals and synthesised key intermediate_7-bromo-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid by simply insertion Cyclopropyl amine into 4-oxo-4H-chromene-3-carboxylic intermediate, Then intermediate carboxylic acidundergoesSuzuki coupling with boronated ester deacety...

1 The isolated spinal cord of the frog (Rana pipiens) was used to examine the structural requirement for the activity of neutral amino acids. The potencies of the aliphatic amino acids, gamma-aminobutyric acid (GABA), beta-alanine and glycine were compared with the potencies of conformationally restricted cyclopentane and cyclohexane amino acid analogues. Both motoneurone hyperpolarizing and pr...

In this study, a quinoline-4-carboxylic acid derivative was synthesized through Pfitzinger reaction. reaction, isatin is modified via its reaction with ketone and refluxed for 24 h to obtain acid. The presence of carboxylic group identified by Fourier Transform Infrared (FTIR) spectroscopy ultraviolet–visible (UV-Vis) spectrophotometry. results showed that the absorption peaks C=O O–H stretchin...

with urease. A third minor metabolite was present in urine collected after intraperitoneal administration but remains unidentified. The quantitative distribution of pterin-dcarboxylic acid and urea in the 0-24 h urine samples is shown in Table 1. Fukushima & Nixon (1980) reported the degradation of [2-14C]pterin-6-carboxylic acid to 14C02 by the gut microorganisms of the rat. It is possible tha...

Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, H NMR, C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2(Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-...

Host odours play a major role in the orientation and host location of blood-feeding mosquitoes. Anopheles gambiae Giles sensu stricto, which is the most important malaria vector in Africa, is a highly anthropophilic mosquito species, and the host-seeking behaviour of the females of this mosquito is guided by volatiles of human origin. Ammonia, lactic acid and several carboxylic acids are known ...